Ajou University 1 article published in JoVE Biology A Method to Study α-Synuclein Toxicity and Aggregation Using a Humanized Yeast Model Hyunhee Kim1, Juwon Jeong1, Changhan Lee1 1Department of Biological Sciences, Ajou University An in vivo physiological model of α-synuclein is required to study and understand the pathogenesis of Parkinson's disease. We describe a method to monitor the cytotoxicity and aggregate formation of α-synuclein using a humanized yeast model.