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Bioengineering

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JoVE Journal Bioengineering
Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue
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Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue

Article DOI: 10.3791/52970-v • 06:17 min • October 23rd, 2015
October 23rd, 2015 •
1, 1, 1, 1, 2, 1
1Department of Biomedical Engineering, Tufts University, 2Department of Pediatrics, University of Connecticut Health Center & Connecticut Children's Medical Center

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Summary
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Insight into the complex actions of the brain requires advanced research tools. Here we demonstrate a novel silk-collagen-based 3D engineered model of neural tissue resembling brain-like architecture. The model can be used to study neuronal network assembly, axonal guidance, cell-cell interactions and electrical activity.

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3D Silk-collagen-based Model Polarized Neural Tissue Brain Anatomy Tissue Engineering Approach Silk And Collagen 3D Brain-like Model White Matter Gray Matter Cortex Rat Brain-derived Neurons Polarized Neuronal Outgrowth Network Formation Axonal Guidance Cell-cell Interactions Cell-matrix Interactions Electrical Functions
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