Cristian Coarfa Department of Molecular and Cellular Biology Baylor College of Medicine Biography Publications Institution JoVE Articles Cristian Coarfa has not added a biography. If you are Cristian Coarfa and would like to personalize this page please email our Author Liaison for assistance. Publications Leveraging Integrated RNA Sequencing to Decipher Adrenomedullin's Protective Mechanisms in Experimental Bronchopulmonary Dysplasia Genes. Jun, 2024 | Pubmed ID: 38927741 is a Synthetic-lethal Target in -mutant Leukemia Cells ELife. Jun, 2024 | Pubmed ID: 38896450 Restrains an Oncogenic Epigenetic Circuit in AT2 Cells to Prevent Ectopic Formation of Fibrogenic Transitional Cell Intermediates and Pulmonary Fibrosis BioRxiv : the Preprint Server for Biology. May, 2024 | Pubmed ID: 38826218 Altered Extracellular Matrix-Related Pathways Accelerate the Transition from Normal to Pre-Fibroid Myometrium in Black Women American Journal of Obstetrics and Gynecology. May, 2024 | Pubmed ID: 38825029 The Maternal and Infant Environmental Health Riskscape Study of Perinatal Disparities in Greater Houston: Rationale, Study Design and Participant Profiles Frontiers in Reproductive Health. 2024 | Pubmed ID: 38712340 Identification of an Early Survival Prognostic Gene Signature for Localized Osteosarcoma Patients Scientific Reports. Mar, 2024 | Pubmed ID: 38538763 Temporal Dynamics of BMP/Nodal Ratio Drive Tissue-specific Gastrulation Morphogenesis BioRxiv : the Preprint Server for Biology. Feb, 2024 | Pubmed ID: 38370754 Distinct Amino Acid Profile Characterizes Youth With or at Risk for Type 2 Diabetes Diabetes. Apr, 2024 | Pubmed ID: 38215171 Genome-wide P63-Target Gene Analyses Reveal TAp63/NRF2-Dependent Oxidative Stress Responses Cancer Research Communications. Feb, 2024 | Pubmed ID: 38165157 D-Mannose Reduces Cellular Senescence and NLRP3/GasderminD/IL-1β-driven Pyroptotic Uroepithelial Cell Shedding in the Murine Bladder Developmental Cell. Jan, 2024 | Pubmed ID: 38101412 Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity Cancer Research. Mar, 2024 | Pubmed ID: 38038968 Metabolomic Rewiring Promotes Endocrine Therapy Resistance in Breast Cancer Cancer Research. Jan, 2024 | Pubmed ID: 37906431 Circadian Dysfunction Induces NAFLD-related Human Liver Cancer in a Mouse Model Journal of Hepatology. Feb, 2024 | Pubmed ID: 37890720 is a Synthetic Lethal Target in -mutant Leukemia Cells BioRxiv : the Preprint Server for Biology. Jan, 2024 | Pubmed ID: 37693622 Infant and Adult Human Intestinal Enteroids Are Morphologically and Functionally Distinct BioRxiv : the Preprint Server for Biology. Feb, 2024 | Pubmed ID: 37292968 Human Intestinal Organoids from Cronkhite-Canada Syndrome Patients Reveal Link Between Serotonin and Proliferation The Journal of Clinical Investigation. Nov, 2023 | Pubmed ID: 37909332 TGFβ Signaling Links Early Life Endocrine-disrupting Chemicals Exposure to Suppression of Nucleotide Excision Repair in Rat Myometrial Stem Cells Cellular and Molecular Life Sciences : CMLS. Sep, 2023 | Pubmed ID: 37689587 Multiomic Investigations into Lung Health and Disease Microorganisms. Aug, 2023 | Pubmed ID: 37630676 Loss of MicroRNA-30a and Sex-specific Effects on the Neonatal Hyperoxic Lung Injury Biology of Sex Differences. Aug, 2023 | Pubmed ID: 37553579 Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Oct, 2023 | Pubmed ID: 37530747 Loss of Cytochrome P450 (CYP)1B1 Mitigates Hyperoxia Response in Adult Mouse Lung by Reprogramming Metabolism and Translation Redox Biology. Aug, 2023 | Pubmed ID: 37348155 TGFβ Signaling Links Early-life Endocrine-disrupting Chemicals Exposure to Suppression of Nucleotide Excision Repair in Rat Myometrial Stem Cells Research Square. Jun, 2023 | Pubmed ID: 37333266 MYC Regulates CSF1 Expression Via MicroRNA 17/20a to Modulate Tumor-associated Macrophages in Osteosarcoma JCI Insight. Jul, 2023 | Pubmed ID: 37279073 Functional Genomic Analysis of Non-canonical DNA Regulatory Elements of the Aryl Hydrocarbon Receptor BioRxiv : the Preprint Server for Biology. May, 2023 | Pubmed ID: 37205451 TRAF4-mediated Nonproteolytic Ubiquitination of Androgen Receptor Promotes Castration-resistant Prostate Cancer Proceedings of the National Academy of Sciences of the United States of America. May, 2023 | Pubmed ID: 37155905 Evolution of Cisplatin Resistance Through Coordinated Metabolic Reprogramming of the Cellular Reductive State British Journal of Cancer. Jun, 2023 | Pubmed ID: 37012319 A Human Stem Cell-derived Neuronal Model of Morphine Exposure Reflects Brain Dysregulation in Opioid Use Disorder: Transcriptomic and Epigenetic Characterization of Postmortem-derived IPSC Neurons Frontiers in Psychiatry. 2023 | Pubmed ID: 36873219 Transcriptome, Proteome, and Protein Synthesis Within the Intracellular Cytomatrix IScience. Feb, 2023 | Pubmed ID: 36824274 Modeling Ewing Sarcoma Lung Metastasis Current Protocols. Feb, 2023 | Pubmed ID: 36799651 PD-L1 Translocation to the Plasma Membrane Enables Tumor Immune Evasion Through MIB2 Ubiquitination The Journal of Clinical Investigation. Feb, 2023 | Pubmed ID: 36719382 Systemic Interindividual Epigenetic Variation in Humans is Associated with Transposable Elements and Under Strong Genetic Control Genome Biology. Jan, 2023 | Pubmed ID: 36631879 Differential Co-expression Networks of the Gut Microbiota Are Associated with Depression and Anxiety Treatment Resistance Among Psychiatric Inpatients Progress in Neuro-psychopharmacology & Biological Psychiatry. Jan, 2023 | Pubmed ID: 36122838 Integrative Metabolomics and Transcriptomics Analysis Reveals Novel Therapeutic Vulnerabilities in Lung Cancer Cancer Medicine. Jan, 2023 | Pubmed ID: 35676822 Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles Cancer Research Communications. Aug, 2022 | Pubmed ID: 36923308 MicroRNA-mRNA Networks Are Dysregulated in Opioid Use Disorder Postmortem Brain: Further Evidence for Opioid-induced Neurovascular Alterations Frontiers in Psychiatry. 2022 | Pubmed ID: 36713930 LncRNA PVT-1 Promotes Osteosarcoma Cancer Stem-like Properties Through Direct Interaction with TRIM28 and TSC2 Ubiquitination Oncogene. Dec, 2022 | Pubmed ID: 36348010 The Rheumatoid Arthritis Drug Auranofin Lowers Leptin Levels and Exerts Antidiabetic Effects in Obese Mice Cell Metabolism. Dec, 2022 | Pubmed ID: 36243005 Sex-specific Epigenetic Development in the Mouse Hypothalamic Arcuate Nucleus Pinpoints Human Genomic Regions Associated with Body Mass Index Science Advances. Sep, 2022 | Pubmed ID: 36170368 Plasma Protein Biomarkers for Primary Graft Dysfunction After Lung Transplantation: a Single-center Cohort Analysis Scientific Reports. Sep, 2022 | Pubmed ID: 36167867 Histopathologic and Transcriptomic Phenotypes of a Conditional RANKL Transgenic Mouse Thymus Cytokine. Dec, 2022 | Pubmed ID: 36099756 Deletion of the Gene in Fibroblasts Causes Senescence-associated Dilated Cardiomyopathy by Activating the Double-stranded DNA Damage Response and Induction of Senescence-associated Secretory Phenotype The Journal of Cardiovascular Aging. Jul, 2022 | Pubmed ID: 35891706 Early Systemic Glycolytic Shift After Aneurysmal Subarachnoid Hemorrhage is Associated with Functional Outcomes Neurocritical Care. Dec, 2022 | Pubmed ID: 35799091 MYCN-driven Fatty Acid Uptake is a Metabolic Vulnerability in Neuroblastoma Nature Communications. Jun, 2022 | Pubmed ID: 35764645 The Prostate Cancer Androgen Receptor Cistrome in African American Men Associates with Upregulation of Lipid Metabolism and Immune Response Cancer Research. Aug, 2022 | Pubmed ID: 35731919 MAB21L4 Deficiency Drives Squamous Cell Carcinoma Via Activation of RET Cancer Research. Sep, 2022 | Pubmed ID: 35705526 Calcium/calmodulin-dependent Protein Kinase Kinase 2 Regulates Hepatic Fuel Metabolism Molecular Metabolism. Aug, 2022 | Pubmed ID: 35562082 High-throughput Profiling of Histone Post-translational Modifications and Chromatin Modifying Proteins by Reverse Phase Protein Array Journal of Proteomics. Jun, 2022 | Pubmed ID: 35489683 Concerted Type I Interferon Signaling in Microglia and Neural Cells Promotes Memory Impairment Associated with Amyloid β Plaques Immunity. May, 2022 | Pubmed ID: 35443157 Cistrome and Transcriptome Analysis Identifies Unique Androgen Receptor (AR) and AR-V7 Splice Variant Chromatin Binding and Transcriptional Activities Scientific Reports. Mar, 2022 | Pubmed ID: 35354884 Metabolome and Microbiome Multi-omics Integration from a Murine Lung Inflammation Model of Bronchopulmonary Dysplasia Pediatric Research. Dec, 2022 | Pubmed ID: 35338351 Author Correction: ΔNp63 Regulates a Common Landscape of Enhancer Associated Genes in Non-small Cell Lung Cancer Nature Communications. Mar, 2022 | Pubmed ID: 35338160 Increased DNA Methylation, Cellular Senescence and Premature Epigenetic Aging in Guinea Pigs and Humans with Tuberculosis Aging. Mar, 2022 | Pubmed ID: 35256539 ISA101 and Nivolumab for HPV-16 Cancer: Updated Clinical Efficacy and Immune Correlates of Response Journal for Immunotherapy of Cancer. Feb, 2022 | Pubmed ID: 35193933 K-Ras and P53 Mouse Model with Molecular Characteristics of Human Rhabdomyosarcoma and Translational Applications Disease Models & Mechanisms. Feb, 2022 | Pubmed ID: 35174853 Gene Expression Signatures Identify Biologically and Clinically Distinct Tuberculosis Endotypes The European Respiratory Journal. Sep, 2022 | Pubmed ID: 35169026 ΔNp63 Regulates a Common Landscape of Enhancer Associated Genes in Non-small Cell Lung Cancer Nature Communications. Feb, 2022 | Pubmed ID: 35105868 Characterization of the COPD Alveolar Niche Using Single-cell RNA Sequencing Nature Communications. Jan, 2022 | Pubmed ID: 35078977 MiR-181a Promotes Multiple Protumorigenic Functions by Targeting TGFβR3 The Journal of Investigative Dermatology. Jul, 2022 | Pubmed ID: 34890627 Correction To: Hormonal Modulation of ESR1 Mutant Metastasis Oncogene. Jan, 2022 | Pubmed ID: 34782721 The EP300/TP53 Pathway, a Suppressor of the Hippo and Canonical WNT Pathways, is Activated in Human Hearts with Arrhythmogenic Cardiomyopathy in the Absence of Overt Heart Failure Cardiovascular Research. May, 2022 | Pubmed ID: 34132777 Single-cell Sequencing of Rotavirus-infected Intestinal Epithelium Reveals Cell-type Specific Epithelial Repair and Tuft Cell Infection Proceedings of the National Academy of Sciences of the United States of America. 11, 2021 | Pubmed ID: 34732579 Nuclear S-nitrosylation Impacts Tissue Regeneration in Zebrafish Nature Communications. Nov, 2021 | Pubmed ID: 34725362 Tuberculosis Endotypes to Guide Stratified Host-directed Therapy Med (New York, N.Y.). Mar, 2021 | Pubmed ID: 34693385 Inhibition of GATA2 in Prostate Cancer by a Clinically Available Small Molecule Endocrine-related Cancer. Nov, 2021 | Pubmed ID: 34636746 Endothelium-specific Depletion of LRP1 Improves Glucose Homeostasis Through Inducing Osteocalcin Nature Communications. Sep, 2021 | Pubmed ID: 34489478 Author Correction: Therapeutically Actionable Signaling Node to Rescue AURKA Driven Loss of Primary Cilia in VHL-deficient Cells Scientific Reports. Aug, 2021 | Pubmed ID: 34462545 CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis Via Metabolic Reprogramming Advanced Science (Weinheim, Baden-Wurttemberg, Germany). Oct, 2021 | Pubmed ID: 34365742 Memory and Naïve Gamma Delta Regulatory T-cell Gene Expression in the First 24-weeks of Peanut Oral Immunotherapy Clinical Immunology (Orlando, Fla.). Sep, 2021 | Pubmed ID: 34365017 A Noncoding RNA Modulator Potentiates Phenylalanine Metabolism in Mice Science (New York, N.Y.). Aug, 2021 | Pubmed ID: 34353949 A Machine Learning Case-control Classifier for Schizophrenia Based on DNA Methylation in Blood Translational Psychiatry. Aug, 2021 | Pubmed ID: 34341337 High Potency STING Agonists Engage Unique Myeloid Pathways to Reverse Pancreatic Cancer Immune Privilege Journal for Immunotherapy of Cancer. Aug, 2021 | Pubmed ID: 34341132 Use of Human Tissue Stem Cell-derived Organoid Cultures to Model Enterohepatic Circulation American Journal of Physiology. Gastrointestinal and Liver Physiology. 09, 2021 | Pubmed ID: 34288725 Effect of Substrate Stiffness on Human Intestinal Enteroids' Infectivity by Enteroaggregative Escherichia Coli Acta Biomaterialia. 09, 2021 | Pubmed ID: 34280559 Esomeprazole Enhances the Effect of Ionizing Radiation to Improve Tumor Control Oncotarget. Jul, 2021 | Pubmed ID: 34262645 Early Detection of Myocardial Changes with and Without Dexrazoxane Using Serial Magnetic Resonance Imaging in a Pre-clinical Mouse Model Cardio-oncology (London, England). Jun, 2021 | Pubmed ID: 34134789 A Wnt-Independent LGR4-EGFR Signaling Axis in Cancer Metastasis Cancer Research. Sep, 2021 | Pubmed ID: 34099494 Effect of Sex Chromosomes Versus Hormones in Neonatal Lung Injury JCI Insight. Jul, 2021 | Pubmed ID: 34061778 Perspectives for Systems Biology in the Management of Tuberculosis European Respiratory Review : an Official Journal of the European Respiratory Society. Jun, 2021 | Pubmed ID: 34039674 Reverse-Phase Protein Array: Technology, Application, Data Processing, and Integration Journal of Biomolecular Techniques : JBT. Apr, 2021 | Pubmed ID: 34025221 Superior Efficacy of Co-targeting GFI1/KDM1A and BRD4 Against AML and Post-MPN Secondary AML Cells Blood Cancer Journal. May, 2021 | Pubmed ID: 34016956 Neuronal SETD2 Activity Links Microtubule Methylation to an Anxiety-like Phenotype in Mice Brain : a Journal of Neurology. Sep, 2021 | Pubmed ID: 34014281 Therapeutically Actionable Signaling Node to Rescue AURKA Driven Loss of Primary Cilia in VHL-deficient Cells Scientific Reports. May, 2021 | Pubmed ID: 34002003 Reverse Phase Protein Array Reveals Correlation of Retinoic Acid Metabolism With Cardiomyopathy in Friedreich's Ataxia Molecular & Cellular Proteomics : MCP. 2021 | Pubmed ID: 33991687 Author Correction: Androgen Receptor and Its Splice Variant, AR-V7, Differentially Induce MRNA Splicing in Prostate Cancer Cells Scientific Reports. May, 2021 | Pubmed ID: 33976356 Plasma MiRNA Biomarkers in Limited Volume Samples for Detection of Early-stage Pancreatic Cancer Cancer Prevention Research (Philadelphia, Pa.). Jul, 2021 | Pubmed ID: 33893071 A Cytoskeletal Function for PBRM1 Reading Methylated Microtubules Science Advances. Apr, 2021 | Pubmed ID: 33811077 A Phase I Dose-Escalation Study to Evaluate the Safety and Tolerability of Evofosfamide in Combination with Ipilimumab in Advanced Solid Malignancies Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2021 | Pubmed ID: 33771853 BET Proteolysis Targeted Chimera-based Therapy of Novel Models of Richter Transformation-diffuse Large B-cell Lymphoma Leukemia. Sep, 2021 | Pubmed ID: 33654205 Altered Metabolic and Inflammatory Transcriptomics After Cardiac Surgery in Neonates with Congenital Heart Disease Scientific Reports. Mar, 2021 | Pubmed ID: 33654130 Reverse-Phase Protein Array: Technology, Application, Data Processing, and Integration Journal of Biomolecular Techniques : JBT. Jan, 2021 | Pubmed ID: 33584151 Constitutive Activation of Mitogen-activated Protein Kinase Kinase (MEK1) in Ileal Enterocytes Leads to Dysplasia and a Predisposition to Cancer American Journal of Physiology. Gastrointestinal and Liver Physiology. Mar, 2021 | Pubmed ID: 33470189 Androgen Receptor and Its Splice Variant, AR-V7, Differentially Induce MRNA Splicing in Prostate Cancer Cells Scientific Reports. Jan, 2021 | Pubmed ID: 33446905 P21-activated Kinases As Viable Therapeutic Targets for the Treatment of High-risk Ewing Sarcoma Oncogene. Feb, 2021 | Pubmed ID: 33414491 Hormonal Modulation of ESR1 Mutant Metastasis Oncogene. Feb, 2021 | Pubmed ID: 33323970 Isoform-specific Activities of Androgen Receptor and Its Splice Variants in Prostate Cancer Cells Endocrinology. Mar, 2021 | Pubmed ID: 33300995 RON Signalling Promotes Therapeutic Resistance in ESR1 Mutant Breast Cancer British Journal of Cancer. Jan, 2021 | Pubmed ID: 33257837 Targeting PAK4 Inhibits Ras-Mediated Signaling and Multiple Oncogenic Pathways in High-Risk Rhabdomyosarcoma Cancer Research. Jan, 2021 | Pubmed ID: 33168646 Haploinsufficiency of Tmem43 in Cardiac Myocytes Activates the DNA Damage Response Pathway Leading to a Late-onset Senescence-associated Pro-fibrotic Cardiomyopathy Cardiovascular Research. Sep, 2021 | Pubmed ID: 33070193 An Actin-WHAMM Interaction Linking SETD2 and Autophagy Biochemical and Biophysical Research Communications. Jun, 2021 | Pubmed ID: 33036756 Coagulopathy in Malnourished Mice Is Sexually Dimorphic and Regulated by Nutrient-Sensing Nuclear Receptors Hepatology Communications. Dec, 2020 | Pubmed ID: 33305154 Integrative Transcriptomic Analysis for Linking Acute Stress Responses to Squamous Cell Carcinoma Development Scientific Reports. Oct, 2020 | Pubmed ID: 33057049 Pan-cancer Analysis Reveals TAp63-regulated Oncogenic LncRNAs That Promote Cancer Progression Through AKT Activation Nature Communications. Oct, 2020 | Pubmed ID: 33056990 STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity Diabetes. Dec, 2020 | Pubmed ID: 32994273 Enteroaggregative E. Coli Adherence to Human Heparan Sulfate Proteoglycans Drives Segment and Host Specific Responses to Infection PLoS Pathogens. 09, 2020 | Pubmed ID: 32986782 Epigenetic Response to Hyperoxia in the Neonatal Lung is Sexually Dimorphic Redox Biology. Oct, 2020 | Pubmed ID: 32961439 Human Norovirus Exhibits Strain-specific Sensitivity to Host Interferon Pathways in Human Intestinal Enteroids Proceedings of the National Academy of Sciences of the United States of America. 09, 2020 | Pubmed ID: 32907944 Correction: Epigenetic Loss of AOX1 Expression Via EZH2 Leads to Metabolic Deregulations and Promotes Bladder Cancer Progression Oncogene. Oct, 2020 | Pubmed ID: 32820250 Large-scale Discovery of Male Reproductive Tract-specific Genes Through Analysis of RNA-seq Datasets BMC Biology. Aug, 2020 | Pubmed ID: 32814578 Identification of Genes and Pathways Regulated by Lamin A in Heart Journal of the American Heart Association. Aug, 2020 | Pubmed ID: 32805188 Targets Gene Networks That Promote Browning of Human and Mouse Adipocytes American Journal of Physiology. Endocrinology and Metabolism. Oct, 2020 | Pubmed ID: 32799658 Identification of Cell Type-specific Methylation Signals in Bulk Whole Genome Bisulfite Sequencing Data Genome Biology. Jul, 2020 | Pubmed ID: 32605651 Acquisition of Cisplatin Resistance Shifts Head and Neck Squamous Cell Carcinoma Metabolism Toward Neutralization of Oxidative Stress Cancers. Jun, 2020 | Pubmed ID: 32599707 BET Bromodomain Inhibition Attenuates Cardiac Phenotype in Myocyte-specific Lamin A/C-deficient Mice The Journal of Clinical Investigation. Sep, 2020 | Pubmed ID: 32484798 Vitamin D Actions in Neurons Require the PI3K Pathway for Both Enhancing Insulin Signaling and Rapid Depolarizing Effects The Journal of Steroid Biochemistry and Molecular Biology. 06, 2020 | Pubmed ID: 32408067 Epigenome Environment Interactions Accelerate Epigenomic Aging and Unlock Metabolically Restricted Epigenetic Reprogramming in Adulthood Nature Communications. May, 2020 | Pubmed ID: 32385268 Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma Cancer Cell. May, 2020 | Pubmed ID: 32359397 Estrogen Receptor-α Expressing Neurons in the Ventrolateral VMH Regulate Glucose Balance Nature Communications. 05, 2020 | Pubmed ID: 32358493 BCL9/STAT3 Regulation of Transcriptional Enhancer Networks Promote DCIS Progression NPJ Breast Cancer. 2020 | Pubmed ID: 32352029 Discovery, Structure-Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP Journal of Medicinal Chemistry. May, 2020 | Pubmed ID: 32314924 Spatiotemporal Regulation of ΔNp63 by TGFβ-Regulated MiRNAs Is Essential for Cancer Metastasis Cancer Research. Jul, 2020 | Pubmed ID: 32312834 TAp63-Regulated MiRNAs Suppress Cutaneous Squamous Cell Carcinoma Through Inhibition of a Network of Cell-Cycle Genes Cancer Research. Jun, 2020 | Pubmed ID: 32156775 DNA Hypermethylation During Tuberculosis Dampens Host Immune Responsiveness The Journal of Clinical Investigation. Jun, 2020 | Pubmed ID: 32125282 Targeting Oncogenic Super Enhancers in MYC-Dependent AML Using a Small Molecule Activator of NR4A Nuclear Receptors Scientific Reports. Feb, 2020 | Pubmed ID: 32071334 Mechanistic Basis and Efficacy of Targeting the β-catenin-TCF7L2-JMJD6-c-Myc Axis to Overcome Resistance to BET Inhibitors Blood. Apr, 2020 | Pubmed ID: 32068780 Bempegaldesleukin Selectively Depletes Intratumoral Tregs and Potentiates T Cell-mediated Cancer Therapy Nature Communications. Jan, 2020 | Pubmed ID: 32005826 A Phase II Study of Cabozantinib and Androgen Ablation in Patients with Hormone-Naïve Metastatic Prostate Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 03, 2020 | Pubmed ID: 31941830 Hepatic Tumor Formation in Adult Mice Developmentally Exposed to Organotin Environmental Health Perspectives. Jan, 2020 | Pubmed ID: 31939706 Metabolic Dysregulation in the Wilson's Disease Mouse Model Proceedings of the National Academy of Sciences of the United States of America. 01, 2020 | Pubmed ID: 31924743 Long Noncoding RNA BHLHE40-AS1 Promotes Early Breast Cancer Progression Through Modulating IL-6/STAT3 Signaling Journal of Cellular Biochemistry. Jul, 2020 | Pubmed ID: 31907974 Critical Role of Cytosolic DNA and Its Sensing Adaptor STING in Aortic Degeneration, Dissection, and Rupture Circulation. Jan, 2020 | Pubmed ID: 31887080 RNA Sequencing-based Transcriptome Profiling of Cardiac Tissue Implicates Novel Putative Disease Mechanisms in FLNC-associated Arrhythmogenic Cardiomyopathy International Journal of Cardiology. Mar, 2020 | Pubmed ID: 31843279 The Testis-specific Serine Proteases PRSS44, PRSS46, and PRSS54 Are Dispensable for Male Mouse Fertility† Biology of Reproduction. 02, 2020 | Pubmed ID: 31403672 Epigenetic Loss of AOX1 Expression Via EZH2 Leads to Metabolic Deregulations and Promotes Bladder Cancer Progression Oncogene. Oct, 2020 | Pubmed ID: 31383940 Exercise Restores Dysregulated Gene Expression in a Mouse Model of Arrhythmogenic Cardiomyopathy Cardiovascular Research. May, 2020 | Pubmed ID: 31350552 Metabolomic Biomarkers Are Associated with Mortality in Patients with Cirrhosis Caused by Primary Biliary Cholangitis or Primary Sclerosing Cholangitis Future Science OA. Dec, 2019 | Pubmed ID: 32025330 MicroRNA-509-3p Inhibits Cellular Migration, Invasion, and Proliferation, and Sensitizes Osteosarcoma to Cisplatin Scientific Reports. Dec, 2019 | Pubmed ID: 31836741 Correction: Expression of Ganglioside GD2, Reprogram the Lipid Metabolism and EMT Phenotype in Bladder Cancer Oncotarget. Nov, 2019 | Pubmed ID: 31827727 DNA Methylation in AgRP Neurons Regulates Voluntary Exercise Behavior in Mice Nature Communications. Dec, 2019 | Pubmed ID: 31792207 Loss of the E2 SUMO-conjugating Enzyme in Oocytes During Ovarian Folliculogenesis Causes Infertility in Mice Development (Cambridge, England). Dec, 2019 | Pubmed ID: 31704792 Erratum to "Distinct Lipidomic Landscapes Associated with Clinical Stages of Urothelial Cancer of the Bladder" [Eur Urol Focus 2018;4:907-915] European Urology Focus. Sep, 2019 | Pubmed ID: 31474581 The Genomic Landscape of Estrogen Receptor α Binding Sites in Mouse Mammary Gland PloS One. 2019 | Pubmed ID: 31408468 Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction Circulation. Jul, 2019 | Pubmed ID: 31356139 DNA Methylation Patterns in Bladder Tumors of African American Patients Point to Distinct Alterations in Xenobiotic Metabolism Carcinogenesis. Nov, 2019 | Pubmed ID: 31284295 Short-term RANKL Exposure Initiates a Neoplastic Transcriptional Program in the Basal Epithelium of the Murine Salivary Gland Cytokine. Nov, 2019 | Pubmed ID: 31226438 Association Between Elevated Placental Polycyclic Aromatic Hydrocarbons (PAHs) and PAH-DNA Adducts from Superfund Sites in Harris County, and Increased Risk of Preterm Birth (PTB) Biochemical and Biophysical Research Communications. Aug, 2019 | Pubmed ID: 31208719 CRISPR/Cas9-mediated Genome Editing Reveals 30 Testis-enriched Genes Dispensable for Male Fertility in Mice† Biology of Reproduction. 08, 2019 | Pubmed ID: 31201419 Mitochondrial Pyruvate Import is a Metabolic Vulnerability in Androgen Receptor-driven Prostate Cancer Nature Metabolism. Jan, 2019 | Pubmed ID: 31198906 Oncogenic LncRNA Downregulates Cancer Cell Antigen Presentation and Intrinsic Tumor Suppression Nature Immunology. Jul, 2019 | Pubmed ID: 31160797 A Genomic Atlas of Systemic Interindividual Epigenetic Variation in Humans Genome Biology. Jun, 2019 | Pubmed ID: 31155008 Cigarette Smoke-induced Reduction of C1q Promotes Emphysema JCI Insight. 05, 2019 | Pubmed ID: 31112138 Transcriptomic Profiling Identifies Novel Mechanisms of Transcriptional Regulation of the Cytochrome P450 (Cyp)3a11 Gene Scientific Reports. Apr, 2019 | Pubmed ID: 31040347 RUNX1-targeted Therapy for AML Expressing Somatic or Germline Mutation in RUNX1 Blood. 07, 2019 | Pubmed ID: 31023702 Activating P53 Family Member TAp63: A Novel Therapeutic Strategy for Targeting P53-altered Tumors Cancer. Jul, 2019 | Pubmed ID: 31012964 REST-DRD2 Mechanism Impacts Glioblastoma Stem Cell-mediated Tumorigenesis Neuro-oncology. Jun, 2019 | Pubmed ID: 30953587 Multi-omics Integration Analysis Robustly Predicts High-Grade Patient Survival and Identifies CPT1B Effect on Fatty Acid Metabolism in Bladder Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2019 | Pubmed ID: 30846479 Tegavivint and the β-Catenin/ALDH Axis in Chemotherapy-Resistant and Metastatic Osteosarcoma Journal of the National Cancer Institute. Nov, 2019 | Pubmed ID: 30793158 Genomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes Is Associated With Differential Gene Expression and DNA Methylation in Human Dilated Cardiomyopathy Circulation Research. Apr, 2019 | Pubmed ID: 30739589 A Prospective Targeted Serum Metabolomics Study of Pancreatic Cancer in Postmenopausal Women Cancer Prevention Research (Philadelphia, Pa.). Apr, 2019 | Pubmed ID: 30723176 DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations Circulation Research. Mar, 2019 | Pubmed ID: 30696354 Superior Efficacy of Cotreatment with BET Protein Inhibitor and BCL2 or MCL1 Inhibitor Against AML Blast Progenitor Cells Blood Cancer Journal. Jan, 2019 | Pubmed ID: 30647404 Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage Cell. Jan, 2019 | Pubmed ID: 30633903 Targeting Nuclear β-catenin As Therapy for Post-myeloproliferative Neoplasm Secondary AML Leukemia. 06, 2019 | Pubmed ID: 30575820 Correction To: The Emerging Roles of Steroid Hormone Receptors in Ductal Carcinoma in Situ (DCIS) of the Breast Journal of Mammary Gland Biology and Neoplasia. Mar, 2019 | Pubmed ID: 30465315 Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA-Sequencing Arthritis & Rheumatology (Hoboken, N.J.). Apr, 2019 | Pubmed ID: 30407753 MicroRNA-30a As a Candidate Underlying Sex-specific Differences in Neonatal Hyperoxic Lung Injury: Implications for BPD American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2019 | Pubmed ID: 30382766 Inositol Polyphosphate 4-phosphatase Type II Regulation of Androgen Receptor Activity Oncogene. Feb, 2019 | Pubmed ID: 30228349 Plasma Urea Cycle Metabolites May Be Useful Biomarkers in Children With Eosinophilic Esophagitis Frontiers in Pediatrics. 2018 | Pubmed ID: 30687688 The Transcription Factor POU3F2 Regulates a Gene Coexpression Network in Brain Tissue from Patients with Psychiatric Disorders Science Translational Medicine. Dec, 2018 | Pubmed ID: 30545964 The Emerging Roles of Steroid Hormone Receptors in Ductal Carcinoma in Situ (DCIS) of the Breast Journal of Mammary Gland Biology and Neoplasia. Dec, 2018 | Pubmed ID: 30338425 TGF-β1 Programmed Myeloid-derived Suppressor Cells (MDSC) Acquire Immune-stimulating and Tumor Killing Activity Capable of Rejecting Established Tumors in Combination with Radiotherapy Oncoimmunology. 2018 | Pubmed ID: 30288358 Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway Through RPIA in Human Endometrial Cancer Cells Scientific Reports. Sep, 2018 | Pubmed ID: 30177747 Allele-specific Epigenome Maps Reveal Sequence-dependent Stochastic Switching at Regulatory Loci Science (New York, N.Y.). Sep, 2018 | Pubmed ID: 30139913 APOBEC Mutation Drives Early-onset Squamous Cell Carcinomas in Recessive Dystrophic Epidermolysis Bullosa Science Translational Medicine. Aug, 2018 | Pubmed ID: 30135250 Correction: MYCN Acts As a Direct Co-regulator of P53 in MYCN Amplified Neuroblastoma Oncotarget. Jul, 2018 | Pubmed ID: 30042831 Unbiased Lipidomic Profiling of Triple-Negative Breast Cancer Tissues Reveals the Association of Sphingomyelin Levels with Patient Disease-Free Survival Metabolites. Jul, 2018 | Pubmed ID: 30011843 MiR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity Diabetes. 12, 2018 | Pubmed ID: 30002134 Expression of Long Noncoding RNA Promotes Glycolysis in Breast Cancer Cancer Research. Aug, 2018 | Pubmed ID: 29967256 Mechanisms of Skeletal Muscle Wasting in a Mouse Model for Myotonic Dystrophy Type 1 Human Molecular Genetics. Aug, 2018 | Pubmed ID: 29771332 MYCN Acts As a Direct Co-regulator of P53 in MYCN Amplified Neuroblastoma Oncotarget. Apr, 2018 | Pubmed ID: 29755654 Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-Specific Immune Changes Journal of Immunology (Baltimore, Md. : 1950). Jul, 2018 | Pubmed ID: 29752313 Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas Cell Reports. Apr, 2018 | Pubmed ID: 29617660 Metabolic Enzyme PFKFB4 Activates Transcriptional Coactivator SRC-3 to Drive Breast Cancer Nature. Apr, 2018 | Pubmed ID: 29615789 The NIEHS TaRGET II Consortium and Environmental Epigenomics Nature Biotechnology. Mar, 2018 | Pubmed ID: 29509741 An Integrative Transcriptomic Approach to Identify Depot Differences in Genes and MicroRNAs in Adipose Tissues from High Fat Fed Mice Oncotarget. Feb, 2018 | Pubmed ID: 29507687 GLUT12 Promotes Prostate Cancer Cell Growth and is Regulated by Androgens and CaMKK2 Signaling Endocrine-related Cancer. Apr, 2018 | Pubmed ID: 29431615 ICG-001 Exerts Potent Anticancer Activity Against Uveal Melanoma Cells Investigative Ophthalmology & Visual Science. Jan, 2018 | Pubmed ID: 29332125 Suppression of Activated FOXO Transcription Factors in the Heart Prolongs Survival in a Mouse Model of Laminopathies Circulation Research. Mar, 2018 | Pubmed ID: 29317431 Epigenetic Supersimilarity of Monozygotic Twin Pairs Genome Biology. Jan, 2018 | Pubmed ID: 29310692 Unique Metabolomic Signature Associated with Hepatorenal Dysfunction and Mortality in Cirrhosis Translational Research : the Journal of Laboratory and Clinical Medicine. May, 2018 | Pubmed ID: 29291380 Distinct TP63 Isoform-Driven Transcriptional Signatures Predict Tumor Progression and Clinical Outcomes Cancer Research. Jan, 2018 | Pubmed ID: 29180475 Distinct Lipidomic Landscapes Associated with Clinical Stages of Urothelial Cancer of the Bladder European Urology Focus. Dec, 2018 | Pubmed ID: 28753886 Expression of Ganglioside GD2, Reprogram the Lipid Metabolism and EMT Phenotype in Bladder Cancer Oncotarget. Nov, 2017 | Pubmed ID: 29221154 EWS-FLI1 and RNA Helicase A Interaction Inhibitor YK-4-279 Inhibits Growth of Neuroblastoma Oncotarget. Nov, 2017 | Pubmed ID: 29212266 Ronin Governs Early Heart Development by Controlling Core Gene Expression Programs Cell Reports. Nov, 2017 | Pubmed ID: 29117561 Systematic Analysis of Human Telomeric Dysfunction Using Inducible Telosome/shelterin CRISPR/Cas9 Knockout Cells Cell Discovery. 2017 | Pubmed ID: 28955502 Pharmacological Inhibition of CaMKK2 with the Selective Antagonist STO-609 Regresses NAFLD Scientific Reports. Sep, 2017 | Pubmed ID: 28924233 A New Mild Hyperthermia Device to Treat Vascular Involvement in Cancer Surgery Scientific Reports. Sep, 2017 | Pubmed ID: 28900126 Tead1 is Required for Maintaining Adult Cardiomyocyte Function, and Its Loss Results in Lethal Dilated Cardiomyopathy JCI Insight. Sep, 2017 | Pubmed ID: 28878117 Tobacco-Specific Carcinogens Induce Hypermethylation, DNA Adducts, and DNA Damage in Bladder Cancer Cancer Prevention Research (Philadelphia, Pa.). Oct, 2017 | Pubmed ID: 28851690 Sexual Dimorphism of the Pulmonary Transcriptome in Neonatal Hyperoxic Lung Injury: Identification of Angiogenesis As a Key Pathway American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2017 | Pubmed ID: 28818871 MiR-130b Directly Targets ARHGAP1 to Drive Activation of a Metastatic CDC42-PAK1-AP1 Positive Feedback Loop in Ewing Sarcoma International Journal of Cancer. Nov, 2017 | Pubmed ID: 28748534 Peroxisomal Biogenesis is Genetically and Biochemically Linked to Carbohydrate Metabolism in Drosophila and Mouse PLoS Genetics. Jun, 2017 | Pubmed ID: 28640802 Vitamin D Receptor Activation Reduces VCaP Xenograft Tumor Growth and Counteracts ERG Activity Despite Induction of TMPRSS2:ERG Oncotarget. Jul, 2017 | Pubmed ID: 28591703 Glutamine Transporters Are Targets of Multiple Oncogenic Signaling Pathways in Prostate Cancer Molecular Cancer Research : MCR. Aug, 2017 | Pubmed ID: 28507054 Elevated TATA-binding Protein Expression Drives Vascular Endothelial Growth Factor Expression in Colon Cancer Oncotarget. Jul, 2017 | Pubmed ID: 28415573 SPOP Regulates Prostate Epithelial Cell Proliferation and Promotes Ubiquitination and Turnover of C-MYC Oncoprotein Oncogene. Aug, 2017 | Pubmed ID: 28414305 Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome Scientific Reports. Apr, 2017 | Pubmed ID: 28377578 Regulation of MiRNA-29c and Its Downstream Pathways in Preneoplastic Progression of Triple-negative Breast Cancer Oncotarget. Mar, 2017 | Pubmed ID: 28160548 Novel BET Protein Proteolysis-targeting Chimera Exerts Superior Lethal Activity Than Bromodomain Inhibitor (BETi) Against Post-myeloproliferative Neoplasm Secondary (s) AML Cells Leukemia. 09, 2017 | Pubmed ID: 28042144 REST Represses MiR-124 and MiR-203 to Regulate Distinct Oncogenic Properties of Glioblastoma Stem Cells Neuro-oncology. Apr, 2017 | Pubmed ID: 28040710 Transcriptional Regulation of Core Autophagy and Lysosomal Genes by the Androgen Receptor Promotes Prostate Cancer Progression Autophagy. Mar, 2017 | Pubmed ID: 27977328 Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis Cancer Cell. Dec, 2016 | Pubmed ID: 27889186 Author Spotlight: Integrating Single-Cell Transcriptomics with Organoid Cultures for Advanced Research and Therapeutic Insights Carolyn Bomidi1, Xi-Lei Zeng1, Victoria Poplaski1, Cristian Coarfa2, Mary K. Estes1, Sarah E. Blutt1 1Department of Molecular Virology and Microbiology, Baylor College of Medicine, 2Department of Molecular and Cellular Biology, Baylor College of Medicine JoVE 66749 Biology
Author Spotlight: Integrating Single-Cell Transcriptomics with Organoid Cultures for Advanced Research and Therapeutic Insights Carolyn Bomidi1, Xi-Lei Zeng1, Victoria Poplaski1, Cristian Coarfa2, Mary K. Estes1, Sarah E. Blutt1 1Department of Molecular Virology and Microbiology, Baylor College of Medicine, 2Department of Molecular and Cellular Biology, Baylor College of Medicine JoVE 66749 Biology