David M. Mosser Department of Cell Biology and Molecular Genetics University of Maryland Biography Publications Institution JoVE Articles David M. Mosser has not added a biography. If you are David M. Mosser and would like to personalize this page please email our Author Liaison for assistance. Publications Skin Fibrosis Associated with Keloid, Scleroderma and Jorge Lobo's Disease (lacaziosis): An Immuno-histochemical Study International Journal of Experimental Pathology. Dec, 2022 | Pubmed ID: 36183172 High-Density-Immune-Complex Regulatory Macrophages Promote Recovery of Experimental Colitis in Mice Inflammation. Jun, 2021 | Pubmed ID: 33394188 Macrophages and the Maintenance of Homeostasis Cellular & Molecular Immunology. Mar, 2021 | Pubmed ID: 32934339 Humoral Immunity in Leishmaniasis - Prevention or Promotion of Parasite Growth? Cytokine: X. Dec, 2020 | Pubmed ID: 33604564 The Transition of M-CSF-derived Human Macrophages to a Growth-promoting Phenotype Blood Advances. Nov, 2020 | Pubmed ID: 33166408 Macrophage Polarization in Intestinal Inflammation and Gut Homeostasis Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]. Dec, 2020 | Pubmed ID: 32886145 Immune Complex-Driven Generation of Human Macrophages with Anti-Inflammatory and Growth-Promoting Activity Journal of Immunology (Baltimore, Md. : 1950). Jul, 2020 | Pubmed ID: 32434940 Immunohistochemical Study of Renal Fibropoiesis Associated with Dogs Naturally and Experimentally Infected with Two Different Strains of Leishmania (L.) Infantum International Journal of Experimental Pathology. Aug, 2019 | Pubmed ID: 31696580 Regulatory Macrophages Inhibit Alternative Macrophage Activation and Attenuate Pathology Associated with Fibrosis Journal of Immunology (Baltimore, Md. : 1950). Oct, 2019 | Pubmed ID: 31541024 Host and Parasite Responses in Human Diffuse Cutaneous Leishmaniasis Caused by L. Amazonensis PLoS Neglected Tropical Diseases. Mar, 2019 | Pubmed ID: 30845223 Monocyte Subpopulations As Important Biomarkers of Resistence and Susceptibility During Experimental Infection with Leishmania (Leishmania) Major Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. Nov, 2018 | Pubmed ID: 30257371 Using a Concept Inventory to Reveal Student Thinking Associated with Common Misconceptions About Antibiotic Resistance Journal of Microbiology & Biology Education. Apr, 2017 | Pubmed ID: 28512513 Macrophages and the Recovery from Acute and Chronic Inflammation Annual Review of Physiology. Feb, 2017 | Pubmed ID: 27959619 Meta-transcriptome Profiling of the Human-Leishmania Braziliensis Cutaneous Lesion PLoS Neglected Tropical Diseases. Sep, 2016 | Pubmed ID: 27631090 OPN-a Induces Muscle Inflammation by Increasing Recruitment and Activation of Pro-inflammatory Macrophages Experimental Physiology. Oct, 2016 | Pubmed ID: 27452303 Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures MBio. May, 2016 | Pubmed ID: 27165796 Complement-mediated 'bystander' Damage Initiates Host NLRP3 Inflammasome Activation Journal of Cell Science. May, 2016 | Pubmed ID: 27006116 Purinergic Signaling to Terminate TLR Responses in Macrophages Frontiers in Immunology. 2016 | Pubmed ID: 26973651 Simultaneous Transcriptional Profiling of Leishmania Major and Its Murine Macrophage Host Cell Reveals Insights into Host-pathogen Interactions BMC Genomics. Dec, 2015 | Pubmed ID: 26715493 IFN-γ Prevents Adenosine Receptor (A2bR) Upregulation To Sustain the Macrophage Activation Response Journal of Immunology (Baltimore, Md. : 1950). Oct, 2015 | Pubmed ID: 26355158 Upregulated IL-1β in Dysferlin-deficient Muscle Attenuates Regeneration by Blunting the Response to Pro-inflammatory Macrophages Skeletal Muscle. 2015 | Pubmed ID: 26251696 Transcriptomic Profiling of Gene Expression and RNA Processing During Leishmania Major Differentiation Nucleic Acids Research. Aug, 2015 | Pubmed ID: 26150419 The Generation of Macrophages with Anti-inflammatory Activity in the Absence of STAT6 Signaling Journal of Leukocyte Biology. Sep, 2015 | Pubmed ID: 26048978 IL-18 Contributes to Susceptibility to Leishmania Amazonensis Infection by Macrophage-independent Mechanisms Cytokine. Aug, 2015 | Pubmed ID: 26009021 Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines Immunity. Jul, 2014 | Pubmed ID: 25035950 Cardiac Macrophages: How to Mend a Broken Heart Immunity. Jan, 2014 | Pubmed ID: 24439261 Pattern Recognition Receptors in Innate Immunity, Host Defense, and Immunopathology Advances in Physiology Education. Dec, 2013 | Pubmed ID: 24292903 Extrinsic and Intrinsic Control of Macrophage Inflammatory Responses Journal of Leukocyte Biology. Nov, 2013 | Pubmed ID: 23964115 TLR Stimulation Initiates a CD39-based Autoregulatory Mechanism That Limits Macrophage Inflammatory Responses Blood. Sep, 2013 | Pubmed ID: 23908469 Measuring Opsonic Phagocytosis Via Fcγ Receptors and Complement Receptors on Macrophages Current Protocols in Immunology. Nov, 2011 | Pubmed ID: 22048802 Editorial: Switching on Arginase in M2 Macrophages Journal of Leukocyte Biology. Nov, 2011 | Pubmed ID: 22045920 Regulatory Macrophages: Setting the Threshold for Therapy European Journal of Immunology. Sep, 2011 | Pubmed ID: 21952805 Platelet Activation Attracts a Subpopulation of Effector Monocytes to Sites of Leishmania Major Infection The Journal of Experimental Medicine. Jun, 2011 | Pubmed ID: 21606505 The Neonatal FcR-mediated Presentation of Immune-complexed Antigen is Associated with Endosomal and Phagosomal PH and Antigen Stability in Macrophages and Dendritic Cells Journal of Immunology (Baltimore, Md. : 1950). Apr, 2011 | Pubmed ID: 21402891 The Regulation of Th1 Responses by the P38 MAPK Journal of Immunology (Baltimore, Md. : 1950). Nov, 2010 | Pubmed ID: 20937847 Intrinsic Antibody-dependent Enhancement of Microbial Infection in Macrophages: Disease Regulation by Immune Complexes The Lancet. Infectious Diseases. Oct, 2010 | Pubmed ID: 20883967 The Influence of IgG Density and Macrophage Fc (gamma) Receptor Cross-linking on Phagocytosis and IL-10 Production Immunology Letters. Oct, 2010 | Pubmed ID: 20670655 The Expression of Exogenous Genes in Macrophages: Obstacles and Opportunities Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19347315 The Expression of Heparin-binding Epidermal Growth Factor-like Growth Factor by Regulatory Macrophages Journal of Immunology (Baltimore, Md. : 1950). Feb, 2009 | Pubmed ID: 19201846 Functional Characterization of Bovine TIRAP and MyD88 in Mediating Bacterial Lipopolysaccharide-induced Endothelial NF-kappaB Activation and Apoptosis Comparative Immunology, Microbiology and Infectious Diseases. Nov, 2009 | Pubmed ID: 18760477 Interleukin-10: New Perspectives on an Old Cytokine Immunological Reviews. Dec, 2008 | Pubmed ID: 19161426 Exploring the Full Spectrum of Macrophage Activation Nature Reviews. Immunology. Dec, 2008 | Pubmed ID: 19029990 Activation of Murine Macrophages Current Protocols in Immunology. Nov, 2008 | Pubmed ID: 19016446 The Isolation and Characterization of Murine Macrophages Current Protocols in Immunology. Nov, 2008 | Pubmed ID: 19016445 Peroxisome Proliferator-activated Receptor-gamma Regulates the Expression of Alveolar Macrophage Macrophage Colony-stimulating Factor Journal of Immunology (Baltimore, Md. : 1950). Jul, 2008 | Pubmed ID: 18566389 NFKB1 Promoter Variation Implicates Shear-induced NOS3 Gene Expression and Endothelial Function in Prehypertensives and Stage I Hypertensives American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2007 | Pubmed ID: 17644577 Monocyte Subpopulations and Their Differentiation Patterns During Infection Journal of Leukocyte Biology. Aug, 2007 | Pubmed ID: 17475785 Reduced Pathology Following Infection with Transgenic Leishmania Major Expressing Murine CD40 Ligand Infection and Immunity. Jun, 2007 | Pubmed ID: 17403867 Activation of the MAPK, ERK, Following Leishmania Amazonensis Infection of Macrophages Journal of Immunology (Baltimore, Md. : 1950). Jan, 2007 | Pubmed ID: 17202371 Leishmania-derived Murine Monocyte Chemoattractant Protein 1 Enhances the Recruitment of a Restrictive Population of CC Chemokine Receptor 2-positive Macrophages Infection and Immunity. Feb, 2007 | Pubmed ID: 17088347 Biochemical and Functional Characterization of Three Activated Macrophage Populations Journal of Leukocyte Biology. Dec, 2006 | Pubmed ID: 16905575 NF-kappaB1 (p50) Homodimers Differentially Regulate Pro- and Anti-inflammatory Cytokines in Macrophages The Journal of Biological Chemistry. Sep, 2006 | Pubmed ID: 16835236 Dynamic and Transient Remodeling of the Macrophage IL-10 Promoter During Transcription Journal of Immunology (Baltimore, Md. : 1950). Jul, 2006 | Pubmed ID: 16818788 ERK Activation Following Macrophage FcgammaR Ligation Leads to Chromatin Modifications at the IL-10 Locus Journal of Immunology (Baltimore, Md. : 1950). Jul, 2005 | Pubmed ID: 15972681 A Sensitive Flow Cytometric Methodology for Studying the Binding of L. Chagasi to Canine Peritoneal Macrophages BMC Infectious Diseases. May, 2005 | Pubmed ID: 15913461 A Role for IgG Immune Complexes During Infection with the Intracellular Pathogen Leishmania The Journal of Experimental Medicine. Mar, 2005 | Pubmed ID: 15753208 Innate Immune Responses to Rhodococcus Equi Journal of Immunology (Baltimore, Md. : 1950). Aug, 2004 | Pubmed ID: 15265925 T Cell Biasing by Activated Dendritic Cells Journal of Immunology (Baltimore, Md. : 1950). Jul, 2004 | Pubmed ID: 15240682 The Many Faces of Macrophage Activation Journal of Leukocyte Biology. Feb, 2003 | Pubmed ID: 12554797 Modulating Macrophage Function with IgG Immune Complexes Journal of Endotoxin Research. 2002 | Pubmed ID: 12697094 A Novel Phenotype for an Activated Macrophage: the Type 2 Activated Macrophage Journal of Leukocyte Biology. Jul, 2002 | Pubmed ID: 12101268 The Modulation of Macrophage Activation by Tyrosine Phosphorylation Frontiers in Bioscience : a Journal and Virtual Library. Jun, 2002 | Pubmed ID: 12045018 Cutting Edge: Biasing Immune Responses by Directing Antigen to Macrophage Fc Gamma Receptors Journal of Immunology (Baltimore, Md. : 1950). Apr, 2002 | Pubmed ID: 11937518 Vaccination Against the Intracellular Pathogens Leishmania Major and L. Amazonensis by Directing CD40 Ligand to Macrophages Infection and Immunity. May, 2001 | Pubmed ID: 11292748 Isolation and Culture of Bone Marrow-Derived Macrophages from Mice Ricardo Gonçalves1, Gabriela Kaliff Teófilo Murta1, Izabela Aparecida de Souza1, David M. Mosser2 1Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, 2Department of Cell Biology and Molecular Genetics, University of Maryland JoVE 64566 Immunology and Infection
Isolation and Culture of Bone Marrow-Derived Macrophages from Mice Ricardo Gonçalves1, Gabriela Kaliff Teófilo Murta1, Izabela Aparecida de Souza1, David M. Mosser2 1Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, 2Department of Cell Biology and Molecular Genetics, University of Maryland JoVE 64566 Immunology and Infection