Edwin S. Iversen Department of Statistical Science Duke University Biography Publications Institution JoVE Articles Edwin S. Iversen has not added a biography. If you are Edwin S. Iversen and would like to personalize this page please email our Author Liaison for assistance. Publications The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3) Cancer Research. Mar, 2020 | Pubmed ID: 31932455 Bridging the Gaps: Using an NHP Model to Predict Single Dose Radiation Absorption in Humans International Journal of Radiation Biology. 01, 2020 | Pubmed ID: 30371121 Genome-wide Analysis of Common Copy Number Variation and Epithelial Ovarian Cancer Risk Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. 07, 2019 | Pubmed ID: 30948450 Impact of Amino Acid Substitutions at Secondary Structures in the BRCT Domains of the Tumor Suppressor BRCA1: Implications for Clinical Annotation The Journal of Biological Chemistry. 04, 2019 | Pubmed ID: 30765603 Rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology International Journal of Molecular Sciences. Aug, 2018 | Pubmed ID: 30134598 Variants in Genes Encoding Small GTPases and Association with Epithelial Ovarian Cancer Susceptibility PloS One. 2018 | Pubmed ID: 29979793 Assessment of the Clinical Relevance of BRCA2 Missense Variants by Functional and Computational Approaches American Journal of Human Genetics. 02, 2018 | Pubmed ID: 29394989 TRPV1 Temperature Activation is Specifically Sensitive to Strong Decreases in Amino Acid Hydrophobicity Scientific Reports. 04, 2017 | Pubmed ID: 28373693 Identification of 12 New Susceptibility Loci for Different Histotypes of Epithelial Ovarian Cancer Nature Genetics. May, 2017 | Pubmed ID: 28346442 Characterization of Dependencies Between Growth and Division in Budding Yeast Journal of the Royal Society, Interface. 02, 2017 | Pubmed ID: 28228543 Functional Assays Provide a Robust Tool for the Clinical Annotation of Genetic Variants of Uncertain Significance NPJ Genomic Medicine. 2016 | Pubmed ID: 28781887 DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament Genetics & Epigenetics. 2016 | Pubmed ID: 27920589 PALB2, CHEK2 and ATM Rare Variants and Cancer Risk: Data from COGS Journal of Medical Genetics. 12, 2016 | Pubmed ID: 27595995 Assessment of Variation in Immunosuppressive Pathway Genes Reveals TGFBR2 to Be Associated with Risk of Clear Cell Ovarian Cancer Oncotarget. 10, 2016 | Pubmed ID: 27533245 Effects of Stone Size on the Comminution Process and Efficiency in Shock Wave Lithotripsy Ultrasound in Medicine & Biology. Nov, 2016 | Pubmed ID: 27515177 Exome Genotyping Arrays to Identify Rare and Low Frequency Variants Associated with Epithelial Ovarian Cancer Risk Human Molecular Genetics. 08, 2016 | Pubmed ID: 27378695 Association Between Prepregnancy Body Mass Index and Gestational Weight Gain with Size, Tempo, and Velocity of Infant Growth: Analysis of the Newborn Epigenetic Study Cohort Childhood Obesity (Print). 06, 2016 | Pubmed ID: 27135650 A Targeted Genetic Association Study of Epithelial Ovarian Cancer Susceptibility Oncotarget. Feb, 2016 | Pubmed ID: 26848776 Mapping Nucleosome Positions Using DNase-seq Genome Research. Mar, 2016 | Pubmed ID: 26772197 Investigation of Exomic Variants Associated with Overall Survival in Ovarian Cancer Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Mar, 2016 | Pubmed ID: 26747452 A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Jan, 2016 | Pubmed ID: 26637267 Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC) Journal of Genetics and Genome Research. 2015 | Pubmed ID: 26807442 Common Variants at the CHEK2 Gene Locus and Risk of Epithelial Ovarian Cancer Carcinogenesis. Nov, 2015 | Pubmed ID: 26424751 Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk Genetic Epidemiology. Dec, 2015 | Pubmed ID: 26399219 Cis-eQTL Analysis and Functional Validation of Candidate Susceptibility Genes for High-grade Serous Ovarian Cancer Nature Communications. Sep, 2015 | Pubmed ID: 26391404 Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Oct, 2015 | Pubmed ID: 26209509 Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2015 | Pubmed ID: 26152742 Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk PloS One. 2015 | Pubmed ID: 26091520 Hosts of Avian Brood Parasites Have Evolved Egg Signatures with Elevated Information Content Proceedings. Biological Sciences. Jul, 2015 | Pubmed ID: 26085586 Genome-wide Significant Risk Associations for Mucinous Ovarian Carcinoma Nature Genetics. Aug, 2015 | Pubmed ID: 26075790 Identification of Six New Susceptibility Loci for Invasive Epithelial Ovarian Cancer Nature Genetics. Feb, 2015 | Pubmed ID: 25581431 Evaluating the Ovarian Cancer Gonadotropin Hypothesis: a Candidate Gene Study Gynecologic Oncology. Mar, 2015 | Pubmed ID: 25528498 Construction and Analysis of the NCI-EDRN Breast Cancer Reference Set for Circulating Markers of Disease Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Feb, 2015 | Pubmed ID: 25471344 Maternal Stress, Preterm Birth, and DNA Methylation at Imprint Regulatory Sequences in Humans Genetics & Epigenetics. 2014 | Pubmed ID: 25512713 A Joint Analysis of Metabolomics and Genetics of Breast Cancer Breast Cancer Research : BCR. 2014 | Pubmed ID: 25091696 Consortium Analysis of Gene and Gene-folate Interactions in Purine and Pyrimidine Metabolism Pathways with Ovarian Carcinoma Risk Molecular Nutrition & Food Research. Oct, 2014 | Pubmed ID: 25066213 Functional Annotation Signatures of Disease Susceptibility Loci Improve SNP Association Analysis BMC Genomics. May, 2014 | Pubmed ID: 24886216 Probing Structure-function Relationships in Missense Variants in the Carboxy-terminal Region of BRCA1 PloS One. 2014 | Pubmed ID: 24845084 Genome-wide Association Study of Subtype-specific Epithelial Ovarian Cancer Risk Alleles Using Pooled DNA Human Genetics. Nov, 2013 | Pubmed ID: 24190013 Molecular Signatures of Epithelial Ovarian Cancer: Analysis of Associations with Tumor Characteristics and Epidemiologic Risk Factors Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Oct, 2013 | Pubmed ID: 23917454 Validation of Ovarian Cancer Gene Expression Signatures for Survival and Subtype in Formalin Fixed Paraffin Embedded Tissues Gynecologic Oncology. Apr, 2013 | Pubmed ID: 23274563 Vitamin D Receptor (VDR) Polymorphisms and Risk of Ovarian Cancer in Caucasian and African American Women Gynecologic Oncology. Dec, 2012 | Pubmed ID: 23262379 Charting the Landscape of Tandem BRCT Domain-mediated Protein Interactions Science Signaling. Sep, 2012 | Pubmed ID: 22990118 ABO Blood Group and Risk of Epithelial Ovarian Cancer Within the Ovarian Cancer Association Consortium Cancer Causes & Control : CCC. Nov, 2012 | Pubmed ID: 22961099 Germline Copy Number Variation and Ovarian Cancer Survival Frontiers in Genetics. 2012 | Pubmed ID: 22891074 Depression in Pregnancy, Infant Birth Weight and DNA Methylation of Imprint Regulatory Elements Epigenetics. Jul, 2012 | Pubmed ID: 22677950 Regular Multivitamin Supplement Use, Single Nucleotide Polymorphisms in ATIC, SHMT2, and SLC46A1, and Risk of Ovarian Carcinoma Frontiers in Genetics. 2012 | Pubmed ID: 22461784 Ovarian Cancer Risk Associated with Inherited Inflammation-related Variants Cancer Research. Mar, 2012 | Pubmed ID: 22282663 Gender-specific Methylation Differences in Relation to Prenatal Exposure to Cigarette Smoke Gene. Feb, 2012 | Pubmed ID: 22202639 Effect of Hysterectomy with Ovarian Preservation on Ovarian Function Obstetrics and Gynecology. Dec, 2011 | Pubmed ID: 22067716 Polymorphisms in Stromal Genes and Susceptibility to Serous Epithelial Ovarian Cancer: a Report from the Ovarian Cancer Association Consortium PloS One. 2011 | Pubmed ID: 21637745 Methylation Variation at IGF2 Differentially Methylated Regions and Maternal Folic Acid Use Before and During Pregnancy Epigenetics : Official Journal of the DNA Methylation Society. Jul, 2011 | Pubmed ID: 21636975 A Computational Method to Classify Variants of Uncertain Significance Using Functional Assay Data with Application to BRCA1 Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Jun, 2011 | Pubmed ID: 21447777 Genetic Variation in Insulin-like Growth Factor 2 May Play a Role in Ovarian Cancer Risk Human Molecular Genetics. Jun, 2011 | Pubmed ID: 21422097 The Role of KRAS Rs61764370 in Invasive Epithelial Ovarian Cancer: Implications for Clinical Testing Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2011 | Pubmed ID: 21385923 Epigenetic Suppression of the TGF-beta Pathway Revealed by Transcriptome Profiling in Ovarian Cancer Genome Research. Jan, 2011 | Pubmed ID: 21156726 Common Alleles in Candidate Susceptibility Genes Associated with Risk and Development of Epithelial Ovarian Cancer International Journal of Cancer. Journal International Du Cancer. May, 2011 | Pubmed ID: 20635389 BAYESIAN MODEL SEARCH AND MULTILEVEL INFERENCE FOR SNP ASSOCIATION STUDIES The Annals of Applied Statistics. Sep, 2010 | Pubmed ID: 21179394 Common Variants at 19p13 Are Associated with Susceptibility to Ovarian Cancer Nature Genetics. Oct, 2010 | Pubmed ID: 20852633 A Genome-wide Association Study Identifies Susceptibility Loci for Ovarian Cancer at 2q31 and 8q24 Nature Genetics. Oct, 2010 | Pubmed ID: 20852632 Association Between DNA Damage Response and Repair Genes and Risk of Invasive Serous Ovarian Cancer PloS One. Apr, 2010 | Pubmed ID: 20386703 Evaluation of Established Breast Cancer Risk Factors As Modifiers of BRCA1 or BRCA2: a Multi-center Case-only Analysis Breast Cancer Research and Treatment. Nov, 2010 | Pubmed ID: 20309627 Variation at 8q24 and 9p24 and Risk of Epithelial Ovarian Cancer Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies. Feb, 2010 | Pubmed ID: 20158306 Polymorphism in the GALNT1 Gene and Epithelial Ovarian Cancer in Non-Hispanic White Women: the Ovarian Cancer Association Consortium Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Feb, 2010 | Pubmed ID: 20142253 Risk of Ovarian Cancer and Inherited Variants in Relapse-associated Genes PloS One. Jan, 2010 | Pubmed ID: 20111712 A Branching Process Model for Flow Cytometry and Budding Index Measurements in Cell Synchrony Experiments The Annals of Applied Statistics. 2009 | Pubmed ID: 21853014 A Genome-wide Association Study Identifies a New Ovarian Cancer Susceptibility Locus on 9p22.2 Nature Genetics. Sep, 2009 | Pubmed ID: 19648919 A Prospective Study of Weight Gain After Premenopausal Hysterectomy Journal of Women's Health (2002). May, 2009 | Pubmed ID: 19445617 Microarray Analysis of Early Stage Serous Ovarian Cancers Shows Profiles Predictive of Favorable Outcome Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2009 | Pubmed ID: 19318476 Association Between Invasive Ovarian Cancer Susceptibility and 11 Best Candidate SNPs from Breast Cancer Genome-wide Association Study Human Molecular Genetics. Jun, 2009 | Pubmed ID: 19304784 Single Nucleotide Polymorphisms in the TP53 Region and Susceptibility to Invasive Epithelial Ovarian Cancer Cancer Research. Mar, 2009 | Pubmed ID: 19276375 Polymorphism in the IL18 Gene and Epithelial Ovarian Cancer in Non-Hispanic White Women Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Dec, 2008 | Pubmed ID: 19064572 Genetic Evidence and Integration of Various Data Sources for Classifying Uncertain Variants into a Single Model Human Mutation. Nov, 2008 | Pubmed ID: 18951437 Global Control of Cell-cycle Transcription by Coupled CDK and Network Oscillators Nature. Jun, 2008 | Pubmed ID: 18463633 Hormonal Risk Factors for Ovarian Cancer in Premenopausal and Postmenopausal Women American Journal of Epidemiology. May, 2008 | Pubmed ID: 18303003 Association of Single Nucleotide Polymorphisms in Glycosylation Genes with Risk of Epithelial Ovarian Cancer Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Feb, 2008 | Pubmed ID: 18268124 A Systematic Genetic Assessment of 1,433 Sequence Variants of Unknown Clinical Significance in the BRCA1 and BRCA2 Breast Cancer-predisposition Genes American Journal of Human Genetics. Nov, 2007 | Pubmed ID: 17924331 Validity of Models for Predicting BRCA1 and BRCA2 Mutations Annals of Internal Medicine. Oct, 2007 | Pubmed ID: 17909205 A Probabilistic Model for Cell Cycle Distributions in Synchrony Experiments Cell Cycle (Georgetown, Tex.). Feb, 2007 | Pubmed ID: 17329975 Characterization of BRCA1 and BRCA2 Mutations in a Large United States Sample Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Feb, 2006 | Pubmed ID: 16484695 Classification of Missense Mutations of Disease Genes Journal of the American Statistical Association. 2005 | Pubmed ID: 18418466 Population-Calibrated Gene Characterization: Estimating Age at Onset Distributions Associated With Cancer Genes Journal of the American Statistical Association. 2005 | Pubmed ID: 18418465 Gene Expression Profiling and Genetic Markers in Glioblastoma Survival Cancer Research. May, 2005 | Pubmed ID: 15899794 Patterns of Gene Expression That Characterize Long-term Survival in Advanced Stage Serous Ovarian Cancers Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2005 | Pubmed ID: 15897565 Gene Expression Phenotypes of Atherosclerosis Arteriosclerosis, Thrombosis, and Vascular Biology. Oct, 2004 | Pubmed ID: 15297278 Integrated Modeling of Clinical and Gene Expression Information for Personalized Prediction of Disease Outcomes Proceedings of the National Academy of Sciences of the United States of America. Jun, 2004 | Pubmed ID: 15152076 Prediction of Optimal Versus Suboptimal Cytoreduction of Advanced-stage Serous Ovarian Cancer with the Use of Microarrays American Journal of Obstetrics and Gynecology. Apr, 2004 | Pubmed ID: 15118612 Clonal Analysis of the Neonatal Mouse Heart using Nearest Neighbor Modeling Melanie Bakovic*1, Devang Thakkar*2, Paige DeBenedittis1, Diana C. Chong1, Michael C. Thomas1, Edwin S. Iversen3, Ravi Karra1,4 1Department of Medicine, Duke University, 2Center for Genomic and Computational Biology, Duke University, 3Department of Statistical Science, Duke University, 4Regeneration Next, Duke University JoVE 61656 Developmental Biology
Clonal Analysis of the Neonatal Mouse Heart using Nearest Neighbor Modeling Melanie Bakovic*1, Devang Thakkar*2, Paige DeBenedittis1, Diana C. Chong1, Michael C. Thomas1, Edwin S. Iversen3, Ravi Karra1,4 1Department of Medicine, Duke University, 2Center for Genomic and Computational Biology, Duke University, 3Department of Statistical Science, Duke University, 4Regeneration Next, Duke University JoVE 61656 Developmental Biology