Marie-José Goumans Department of Molecular Cell Biology Leiden University Medical Center Biography Publications Institution JoVE Articles Marie-José Goumans has not added a biography. If you are Marie-José Goumans and would like to personalize this page please email our Author Liaison for assistance. Publications Structural and Cellular Mechanisms of Peptidyl-prolyl Isomerase Pin1-mediated Enhancement of Tissue Factor Gene Expression, Protein Half-life, and Pro-coagulant Activity Haematologica. Mar, 2018 | Pubmed ID: 29545340 Endothelial Dysfunction in Pulmonary Arterial Hypertension: Loss of Cilia Length Regulation Upon Cytokine Stimulation Pulmonary Circulation. Apr-Jun, 2018 | Pubmed ID: 29480152 The Morphological and Molecular Mechanisms of Epithelial/endothelial-to-mesenchymal Transition and Its Involvement in Atherosclerosis Vascular Pharmacology. Feb, 2018 | Pubmed ID: 29471141 Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension Circulation. Feb, 2018 | Pubmed ID: 29167228 The Epicardium As a Source of Multipotent Adult Cardiac Progenitor Cells: Their Origin, Role and Fate Pharmacological Research. 01, 2018 | Pubmed ID: 28751220 Leukocyte-Associated Immunoglobulin-like Receptor-1 is Regulated in Human Myocardial Infarction but Its Absence Does Not Affect Infarct Size in Mice Scientific Reports. Dec, 2017 | Pubmed ID: 29269840 Inhibiting DPP4 in a Mouse Model of HHT1 Results in a Shift Towards Regenerative Macrophages and Reduces Fibrosis After Myocardial Infarction PloS One. 2017 | Pubmed ID: 29253907 Thoracic Aortic Aneurysm Development in Patients with Bicuspid Aortic Valve: What Is the Role of Endothelial Cells? Frontiers in Physiology. 2017 | Pubmed ID: 29249976 Human Cardiomyocyte Progenitor Cells in Co-culture with Rat Cardiomyocytes Form a Pro-arrhythmic Substrate: Evidence for Two Different Arrhythmogenic Mechanisms Frontiers in Physiology. 2017 | Pubmed ID: 29075204 Preeclampsia and Coronary Plaque Erosion: Manifestations of Endothelial Dysfunction Resulting in Cardiovascular Events in Women European Journal of Pharmacology. Dec, 2017 | Pubmed ID: 28899695 Glycosylated Cell Surface Markers for the Isolation of Human Cardiac Progenitors Stem Cells and Development. Nov, 2017 | Pubmed ID: 28891400 Bone Morphogenetic Protein 9 Protects Against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation Frontiers in Physiology. 2017 | Pubmed ID: 28751863 TGFβ1-induced SMAD2/3 and SMAD1/5 Phosphorylation Are Both ALK5-kinase-dependent in Primary Chondrocytes and Mediated by TAK1 Kinase Activity Arthritis Research & Therapy. May, 2017 | Pubmed ID: 28569204 TGFβ Pathway Deregulation and Abnormal Phospho-SMAD2/3 Staining in Hereditary Cerebral Hemorrhage with Amyloidosis-Dutch Type Brain Pathology (Zurich, Switzerland). May, 2017 | Pubmed ID: 28557134 Higher Functionality of Extracellular Vesicles Isolated Using Size-exclusion Chromatography Compared to Ultracentrifugation Nanomedicine : Nanotechnology, Biology, and Medicine. Mar, 2017 | Pubmed ID: 28365418 Bone Morphogenetic Proteins in Vascular Homeostasis and Disease Cold Spring Harbor Perspectives in Biology. Mar, 2017 | Pubmed ID: 28348038 TGF-β Signaling in Control of Cardiovascular Function Cold Spring Harbor Perspectives in Biology. Mar, 2017 | Pubmed ID: 28348036 BMP-9 Interferes with Liver Regeneration and Promotes Liver Fibrosis Gut. May, 2017 | Pubmed ID: 28336518 Mimicking Cardiac Fibrosis in a Dish: Fibroblast Density Rather Than Collagen Density Weakens Cardiomyocyte Function Journal of Cardiovascular Translational Research. Apr, 2017 | Pubmed ID: 28281243 Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair Circulation. May, 2017 | Pubmed ID: 28167635 Phenotypic Screen for Cardiac Regeneration Identifies Molecules with Differential Activity in Human Epicardium-Derived Cells Versus Cardiac Fibroblasts ACS Chemical Biology. 01, 2017 | Pubmed ID: 28103692 The Microvasculature: The Next Battlefield Where Transforming Growth Factor-β and Endoglin Draw Their Double-Edged Swords? Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2017 | Pubmed ID: 28062457 Part and Parcel of the Cardiac Autonomic Nerve System: Unravelling Its Cellular Building Blocks During Development Journal of Cardiovascular Development and Disease. Sep, 2016 | Pubmed ID: 29367572 Long-term Self-renewing Human Epicardial Cells Generated from Pluripotent Stem Cells Under Defined Xeno-free Conditions Nature Biomedical Engineering. 2016 | Pubmed ID: 28462012 Human Fetal and Adult Epicardial-derived Cells: a Novel Model to Study Their Activation Stem Cell Research & Therapy. 11, 2016 | Pubmed ID: 27899163 Cardiomyocyte Progenitor Cell Mechanoresponse Unrevealed: Strain Avoidance and Mechanosome Development Integrative Biology : Quantitative Biosciences from Nano to Macro. 09, 2016 | Pubmed ID: 27722606 Comparative Transcriptomic Analysis Identifies Genes Differentially Expressed in Human Epicardial Progenitors and HiPSC-derived Cardiac Progenitors Physiological Genomics. Nov, 2016 | Pubmed ID: 27591124 Response by Van Der Bruggen Et Al to Letter Regarding Article, "Bone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial Hypertension: A View on the Right Ventricle" Circulation. Aug, 2016 | Pubmed ID: 27572883 Exosomes from Cardiomyocyte Progenitor Cells and Mesenchymal Stem Cells Stimulate Angiogenesis Via EMMPRIN Advanced Healthcare Materials. Aug, 2016 | Pubmed ID: 27570124 Bone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial Hypertension: A View on the Right Ventricle Circulation. May, 2016 | Pubmed ID: 26984938 Cardiac Stem Cell Treatment in Myocardial Infarction: A Systematic Review and Meta-Analysis of Preclinical Studies Circulation Research. Apr, 2016 | Pubmed ID: 26888636 Measuring the Primary Cilium Length: Improved Method for Unbiased High-throughput Analysis Cilia. 2016 | Pubmed ID: 26870322 Age-Dependent Changes in Geometry, Tissue Composition and Mechanical Properties of Fetal to Adult Cryopreserved Human Heart Valves PloS One. 2016 | Pubmed ID: 26867221 The Roadmap of WT1 Protein Expression in the Human Fetal Heart Journal of Molecular and Cellular Cardiology. Jan, 2016 | Pubmed ID: 26686990 Regulatory RNAs Controlling Vascular (dys)function by Affecting TGF-ß Family Signalling EXCLI Journal. 2015 | Pubmed ID: 26862319 Xenotransplantation of Human Cardiomyocyte Progenitor Cells Does Not Improve Cardiac Function in a Porcine Model of Chronic Ischemic Heart Failure. Results from a Randomized, Blinded, Placebo Controlled Trial PloS One. 2015 | Pubmed ID: 26678993 The Epicardium As Modulator of the Cardiac Autonomic Response During Early Development Journal of Molecular and Cellular Cardiology. Dec, 2015 | Pubmed ID: 26527381 Environmental Influences on Endothelial to Mesenchymal Transition in Developing Implanted Cardiovascular Tissue-Engineered Grafts Tissue Engineering. Part B, Reviews. Oct, 2015 | Pubmed ID: 26414174 Regional Differences in WT-1 and Tcf21 Expression During Ventricular Development: Implications for Myocardial Compaction PloS One. 2015 | Pubmed ID: 26390289 Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2015 | Pubmed ID: 26373572 Behavior of CMPCs in Unidirectional Constrained and Stress-free 3D Hydrogels Journal of Molecular and Cellular Cardiology. Aug, 2015 | Pubmed ID: 26278995 Histopathology of Aortic Complications in Bicuspid Aortic Valve Versus Marfan Syndrome: Relevance for Therapy? Heart and Vessels. Jul, 2015 | Pubmed ID: 26129868 Mononuclear Cells and Vascular Repair in HHT Frontiers in Genetics. 2015 | Pubmed ID: 25852751 Mutations in a TGF-β Ligand, TGFB3, Cause Syndromic Aortic Aneurysms and Dissections Journal of the American College of Cardiology. Apr, 2015 | Pubmed ID: 25835445 Functional Maturation of Human Pluripotent Stem Cell Derived Cardiomyocytes in Vitro--correlation Between Contraction Force and Electrophysiology Biomaterials. May, 2015 | Pubmed ID: 25771005 Cardiac Endothelial Cells Express Wilms' Tumor-1: Wt1 Expression in the Developing, Adult and Infarcted Heart Journal of Molecular and Cellular Cardiology. Apr, 2015 | Pubmed ID: 25681586 SLUG is Expressed in Endothelial Cells Lacking Primary Cilia to Promote Cellular Calcification Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2015 | Pubmed ID: 25633317 Inhibition of TGFβ Type I Receptor Activity Facilitates Liver Regeneration Upon Acute CCl4 Intoxication in Mice Archives of Toxicology. Jan, 2015 | Pubmed ID: 25566828 Bicuspid Aortic Valve: Phosphorylation of C-Kit and Downstream Targets Are Prognostic for Future Aortopathy European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery. Nov, 2014 | Pubmed ID: 25161185 The MicroRNA-15 Family Inhibits the TGFβ-pathway in the Heart Cardiovascular Research. Oct, 2014 | Pubmed ID: 25103110 A Straightforward Guide to the Basic Science Behind Cardiovascular Cell-based Therapies Heart (British Cardiac Society). Aug, 2014 | Pubmed ID: 24993501 A Multistep Procedure to Prepare Pre-vascularized Cardiac Tissue Constructs Using Adult Stem Sells, Dynamic Cell Cultures, and Porous Scaffolds Frontiers in Physiology. 2014 | Pubmed ID: 24917827 Nuclear Receptor NR4A1 Promotes Breast Cancer Invasion and Metastasis by Activating TGF-β Signalling Nature Communications. 2014 | Pubmed ID: 24584437 Ascending Aorta Dilation in Association with Bicuspid Aortic Valve: a Maturation Defect of the Aortic Wall The Journal of Thoracic and Cardiovascular Surgery. Oct, 2014 | Pubmed ID: 24560417 ENDOGLIN is Dispensable for Vasculogenesis, but Required for Vascular Endothelial Growth Factor-induced Angiogenesis PloS One. 2014 | Pubmed ID: 24489709 Novel Ex Vivo Culture Method for the Study of Dupuytren's Disease: Effects of TGFβ Type 1 Receptor Modulation by Antisense Oligonucleotides Molecular Therapy. Nucleic Acids. 2014 | Pubmed ID: 24448195 Extraembryonic Endoderm Cells As a Model of Endoderm Development Development, Growth & Differentiation. Apr, 2013 | Pubmed ID: 23414197 Deficiency for Endoglin in Tumor Vasculature Weakens the Endothelial Barrier to Metastatic Dissemination The Journal of Experimental Medicine. Mar, 2013 | Pubmed ID: 23401487 Bone Marrow Alterations and Lower Endothelial Progenitor Cell Numbers in Critical Limb Ischemia Patients PloS One. 2013 | Pubmed ID: 23383236 Cardiac Regeneration: Stem Cells and Beyond Current Medicinal Chemistry. 2012 | Pubmed ID: 22963568 TGFβ and BMP Signaling in Cardiac Cushion Formation: Lessons from Mice and Chicken Differentiation; Research in Biological Diversity. Jul, 2012 | Pubmed ID: 22656450 The Arterial and Cardiac Epicardium in Development, Disease and Repair Differentiation; Research in Biological Diversity. Jul, 2012 | Pubmed ID: 22652098 Isolation and Differentiation of Human Cardiomyocyte Progenitor Cells into Cardiomyocytes Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22610569 Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting The Journal of Biological Chemistry. May, 2012 | Pubmed ID: 22493445 Gap Junctional Coupling with Cardiomyocytes is Necessary but Not Sufficient for Cardiomyogenic Differentiation of Cocultured Human Mesenchymal Stem Cells Stem Cells (Dayton, Ohio). Jun, 2012 | Pubmed ID: 22438316 Shear Induced Collateral Artery Growth Modulated by Endoglin but Not by ALK1 Journal of Cellular and Molecular Medicine. Oct, 2012 | Pubmed ID: 22436015 TGF-β Signaling in Endothelial-to-mesenchymal Transition: the Role of Shear Stress and Primary Cilia Science Signaling. Feb, 2012 | Pubmed ID: 22355187 Cardiomyogenic Differentiation-independent Improvement of Cardiac Function by Human Cardiomyocyte Progenitor Cell Injection in Ischaemic Mouse Hearts Journal of Cellular and Molecular Medicine. Jul, 2012 | Pubmed ID: 22003890 Age-dependent Alteration of TGF-β Signalling in Osteoarthritis Cell and Tissue Research. Jan, 2012 | Pubmed ID: 21638205 Human Embryonic and Fetal Mesenchymal Stem Cells Differentiate Toward Three Different Cardiac Lineages in Contrast to Their Adult Counterparts PloS One. 2011 | Pubmed ID: 21931658 Controlling Angiogenesis by Two Unique TGF-β Type I Receptor Signaling Pathways Histology and Histopathology. Sep, 2011 | Pubmed ID: 21751154 Shedding New Light on the Mechanism Underlying Stem Cell Therapy for the Heart Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2011 | Pubmed ID: 21720378 TGF-β Receptor Signaling Pathways in Angiogenesis; Emerging Targets for Anti-Angiogenesis Therapy Current Pharmaceutical Biotechnology. May, 2011 | Pubmed ID: 21619534 Tgfβ/Alk5 Signaling is Required for Shear Stress Induced Klf2 Expression in Embryonic Endothelial Cells Developmental Dynamics : an Official Publication of the American Association of Anatomists. Jul, 2011 | Pubmed ID: 21604321 In Vitro Epithelial-to-mesenchymal Transformation in Human Adult Epicardial Cells is Regulated by TGFβ-signaling and WT1 Basic Research in Cardiology. Sep, 2011 | Pubmed ID: 21516490 Lack of Primary Cilia Primes Shear-induced Endothelial-to-mesenchymal Transition Circulation Research. Apr, 2011 | Pubmed ID: 21393577 Low Oxygen Tension Positively Influences Cardiomyocyte Progenitor Cell Function Journal of Cellular and Molecular Medicine. Dec, 2011 | Pubmed ID: 21306557 Epithelial-to-mesenchymal Transformation Alters Electrical Conductivity of Human Epicardial Cells Journal of Cellular and Molecular Medicine. Dec, 2011 | Pubmed ID: 21251220 Modulation of TGF-β/BMP-6 Expression and Increased Levels of Circulating Smooth Muscle Progenitor Cells in a Type I Diabetes Mouse Model Cardiovascular Diabetology. 2010 | Pubmed ID: 20858224 Cardiac Malformations in Pdgfralpha Mutant Embryos Are Associated with Increased Expression of WT1 and Nkx2.5 in the Second Heart Field Developmental Dynamics : an Official Publication of the American Association of Anatomists. Aug, 2010 | Pubmed ID: 20658695 Signaling by Members of the TGF-beta Family in Vascular Morphogenesis and Disease Trends in Cell Biology. Sep, 2010 | Pubmed ID: 20656490 Foetal and Adult Cardiomyocyte Progenitor Cells Have Different Developmental Potential Journal of Cellular and Molecular Medicine. Apr, 2010 | Pubmed ID: 20219011 Genetic and Pharmacological Targeting of Activin Receptor-like Kinase 1 Impairs Tumor Growth and Angiogenesis The Journal of Experimental Medicine. Jan, 2010 | Pubmed ID: 20065063 ALK2 R206H Mutation Linked to Fibrodysplasia Ossificans Progressiva Confers Constitutive Activity to the BMP Type I Receptor and Sensitizes Mesenchymal Cells to BMP-induced Osteoblast Differentiation and Bone Formation Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jun, 2010 | Pubmed ID: 19929436 A New Direction for Cardiac Regeneration Therapy: Application of Synergistically Acting Epicardium-derived Cells and Cardiomyocyte Progenitor Cells Circulation. Heart Failure. Nov, 2009 | Pubmed ID: 19919990 VEGF and Inhibitors of TGFbeta Type-I Receptor Kinase Synergistically Promote Blood-vessel Formation by Inducing Alpha5-integrin Expression Journal of Cell Science. Sep, 2009 | Pubmed ID: 19706683 A New in Vitro Model for Stem Cell Differentiation and Interaction Stem Cell Research. Mar, 2009 | Pubmed ID: 19383416 TGF-beta Signaling in Vascular Biology and Dysfunction Cell Research. Jan, 2009 | Pubmed ID: 19114994 Transforming Growth Factor Beta-induced Endothelial-to-mesenchymal Transition: a Switch to Cardiac Fibrosis? Trends in Cardiovascular Medicine. Nov, 2008 | Pubmed ID: 19345316 Endoglin in Angiogenesis and Vascular Diseases Angiogenesis. 2008 | Pubmed ID: 18283546 Smad7 and Protein Phosphatase 1alpha Are Critical Determinants in the Duration of TGF-beta/ALK1 Signaling in Endothelial Cells BMC Cell Biology. 2006 | Pubmed ID: 16571110 Yalıtım ve kültür insan yetişkin ve Fetal kalp örnekler elde edilen birincil Epicardial hücre Esther Dronkers1, Asja T. Moerkamp1, Tessa van Herwaarden1, Marie-José Goumans1, Anke M. Smits1 1Department of Molecular Cell Biology, Leiden University Medical Center JoVE 57370 Developmental Biology
Yalıtım ve kültür insan yetişkin ve Fetal kalp örnekler elde edilen birincil Epicardial hücre Esther Dronkers1, Asja T. Moerkamp1, Tessa van Herwaarden1, Marie-José Goumans1, Anke M. Smits1 1Department of Molecular Cell Biology, Leiden University Medical Center JoVE 57370 Developmental Biology