Shijun Wang Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences Fudan University Biography Publications Institution JoVE Articles Shijun Wang has not added a biography. If you are Shijun Wang and would like to personalize this page please email our Author Liaison for assistance. Publications CXCR6 Mediates Pressure Overload-Induced Aortic Stiffness by Increasing Macrophage Recruitment and Reducing Exosome-miRNA29b Journal of Cardiovascular Translational Research. Aug, 2022 | Pubmed ID: 36018423 Editorial: Mitochondrial Metabolism in Ischemic Heart Disease Frontiers in Cardiovascular Medicine. 2022 | Pubmed ID: 35833188 PCSK9 Participates in Oxidized-low Density Lipoprotein-induced Myocardial Injury Through Mitochondrial Oxidative Stress and Drp1-mediated Mitochondrial Fission Clinical and Translational Medicine. 02, 2022 | Pubmed ID: 35184412 Interleukin-18 Accelerates Cardiac Inflammation and Dysfunction During Ischemia/reperfusion Injury by Transcriptional Activation of CXCL16 Cellular Signalling. 11, 2021 | Pubmed ID: 34487815 Hypertrophic Preconditioning Attenuates Post-myocardial Infarction Injury Through Deacetylation of Isocitrate Dehydrogenase 2 Acta Pharmacologica Sinica. Dec, 2021 | Pubmed ID: 34163022 Cryptotanshinone Inhibits ERα-Dependent and -Independent BCRP Oligomer Formation to Reverse Multidrug Resistance in Breast Cancer Frontiers in Oncology. 2021 | Pubmed ID: 33968724 Fluorescence Live Cell Imaging Revealed Wogonin Targets Mitochondria Talanta. Aug, 2021 | Pubmed ID: 33934785 Caspase-1 Abrogates the Salutary Effects of Hypertrophic Preconditioning in Pressure Overload Hearts Via IL-1β and IL-18 Frontiers in Molecular Biosciences. 2021 | Pubmed ID: 33842546 20()-ginsenoside Rh2 Induces Caspase-dependent Promyelocytic Leukemia-retinoic Acid Receptor A Degradation in NB4 Cells Via Akt/Bax/caspase9 and TNF-α/caspase8 Signaling Cascades Journal of Ginseng Research. Mar, 2021 | Pubmed ID: 33841010 Coix Lacryma-jobi Seed Oil Reduces Fat Accumulation in Nonalcoholic Fatty Liver Disease by Inhibiting the Activation of the P-AMPK/SePP1/apoER2 Pathway Journal of Oleo Science. May, 2021 | Pubmed ID: 33840662 Research Progress on the Pharmacological Effect and Clinical Application of Tongqiao Huoxue Decoction in the Treatment of Ischaemic Stroke Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. Jun, 2021 | Pubmed ID: 33711554 Activation of CXCL16/CXCR6 Axis Aggravates Cardiac Ischemia/reperfusion Injury by Recruiting the IL-17a-producing CD1d T Cells Clinical and Translational Medicine. 02, 2021 | Pubmed ID: 33634988 ShengMai-San Attenuates Cardiac Remodeling in Diabetic Rats by Inhibiting NOX-Mediated Oxidative Stress Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy. 2021 | Pubmed ID: 33603429 Curcumol Inhibits KLF5-dependent Angiogenesis by Blocking the ROS/ERK Signaling in Liver Sinusoidal Endothelial Cells Life Sciences. Jan, 2021 | Pubmed ID: 33157090 Regulation of Hepatic Stellate Cell Contraction and Cirrhotic Portal Hypertension by Wnt/β-catenin Signalling Via Interaction with Gli1 British Journal of Pharmacology. Jun, 2021 | Pubmed ID: 33085791 Protective Effects of Cardiac Resynchronization Therapy in a Canine Model with Experimental Heart Failure by Improving Mitochondrial Function: a Mitochondrial Proteomics Study Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing. Jun, 2021 | Pubmed ID: 32488750 Depression with Comorbid Diabetes: What Evidence Exists for Treatments Using Traditional Chinese Medicine and Natural Products? Frontiers in Pharmacology. 2020 | Pubmed ID: 33568996 Variations in Energy Metabolism Precede Alterations in Cardiac Structure and Function in Hypertrophic Preconditioning Frontiers in Cardiovascular Medicine. 2020 | Pubmed ID: 33426002 From the Perspective of Traditional Chinese Medicine: Treatment of Mental Disorders in COVID-19 Survivors Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. Dec, 2020 | Pubmed ID: 33053508 Novel Copper Complex CTB Regulates Methionine Cycle Induced TERT Hypomethylation to Promote HCC Cells Senescence Via Mitochondrial SLC25A26 Cell Death & Disease. 10, 2020 | Pubmed ID: 33041323 Iron Regulatory Protein 2 is Required for Artemether -mediated Anti-hepatic Fibrosis Through Ferroptosis Pathway Free Radical Biology & Medicine. 11, 2020 | Pubmed ID: 32947011 The BRD7-P53-SLC25A28 Axis Regulates Ferroptosis in Hepatic Stellate Cells Redox Biology. 09, 2020 | Pubmed ID: 32863216 Chinese Herbal Medicine Baoyuan Jiedu Decoction Inhibits the Accumulation of Myeloid Derived Suppressor Cells in Pre-metastatic Niche of Lung Via TGF-β/CCL9 Pathway Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. Sep, 2020 | Pubmed ID: 32554250 HIF-1α-upregulated LncRNA-H19 Regulates Lipid Droplet Metabolism Through the AMPKα Pathway in Hepatic Stellate Cells Life Sciences. Aug, 2020 | Pubmed ID: 32445757 Blockade of Periostin-dependent Migration and Adhesion by Curcumol Via Inhibition of Nuclear Factor Kappa B Signaling in Hepatic Stellate Cells Toxicology. 07, 2020 | Pubmed ID: 32344006 Zi Shen Huo Luo Formula Enhances the Therapeutic Effects of Angiotensin-Converting Enzyme Inhibitors on Hypertensive Left Ventricular Hypertrophy by Interfering With Aldosterone Breakthrough and Affecting Caveolin-1/Mineralocorticoid Receptor Colocalization and Downstream Extracellular Signal-Regulated Kinase Signaling Frontiers in Pharmacology. 2020 | Pubmed ID: 32317965 Left Ventricular Response in the Transition from Hypertrophy to Failure Recapitulates Distinct Roles of Akt, β-arrestin-2, and CaMKII in Mice with Aortic Regurgitation Annals of Translational Medicine. Mar, 2020 | Pubmed ID: 32309366 Oroxylin a Promotes PGC-1α/Mfn2 Signaling to Attenuate Hepatocyte Pyroptosis Via Blocking Mitochondrial ROS in Alcoholic Liver Disease Free Radical Biology & Medicine. 06, 2020 | Pubmed ID: 32289481 A Novel LncRNA PLK4 Up-regulated by Talazoparib Represses Hepatocellular Carcinoma Progression by Promoting YAP-mediated Cell Senescence Journal of Cellular and Molecular Medicine. 05, 2020 | Pubmed ID: 32243714 Transforming Growth Factor β1 is a Differentially Expressed Candidate Protein of Congestive Heart Failure with Qi-deficiency-blood-stasis Syndrome Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan. 04, 2020 | Pubmed ID: 32242397 Antidepressant Mechanism of Classical Herbal Formula Lily Bulb and Rehmannia Decoction: Insights from Gene Expression Profile of Medial Prefrontal Cortex of Mice with Stress-induced Depression-like Behavior Genes, Brain, and Behavior. 06, 2020 | Pubmed ID: 32129566 Curcumol Attenuates Liver Sinusoidal Endothelial Cell Angiogenesis Via Regulating Glis-PROX1-HIF-1α in Liver Fibrosis Cell Proliferation. Mar, 2020 | Pubmed ID: 32119185 Liver Regeneration in Traditional Chinese Medicine: Advances and Challenges Regenerative Medicine Research. 2020 | Pubmed ID: 31939733 Innate Lymphoid Cells: Regulators of Gut Barrier Function and Immune Homeostasis Journal of Immunology Research. 2019 | Pubmed ID: 31930146 Oroxylin A Regulates the Turnover of Lipid Droplet Via Downregulating Adipose Triglyceride Lipase (ATGL) in Hepatic Stellate Cells Life Sciences. Dec, 2019 | Pubmed ID: 31610205 Oroxylin A Induces Apoptosis of Activated Hepatic Stellate Cells Through Endoplasmic Reticulum Stress Apoptosis : an International Journal on Programmed Cell Death. 12, 2019 | Pubmed ID: 31538267 The Molecular Mechanism Underlying GABAergic Dysfunction in Nucleus Accumbens of Depression-like Behaviours in Mice Journal of Cellular and Molecular Medicine. 10, 2019 | Pubmed ID: 31430030 A Complex Role for Calcium Signaling in Colorectal Cancer Development and Progression Molecular Cancer Research : MCR. 11, 2019 | Pubmed ID: 31366605 Peroxisome Proliferator-Activated Receptor-γ Antagonizes LOX-1-Mediated Endothelial Injury by Transcriptional Activation of MiR-590-5p PPAR Research. 2019 | Pubmed ID: 31354796 Beta-elemene Inhibits Breast Cancer Metastasis Through Blocking Pyruvate Kinase M2 Dimerization and Nuclear Translocation Journal of Cellular and Molecular Medicine. 10, 2019 | Pubmed ID: 31343107 High-Resistant Starch, Low-Protein Flour Intervention on Patients With Early Type 2 Diabetic Nephropathy: A Randomized Trial Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation. 09, 2019 | Pubmed ID: 30982743 Identification of Key Genes, Pathways, and MiRNA/mRNA Regulatory Networks of CUMS-induced Depression in Nucleus Accumbens by Integrated Bioinformatics Analysis Neuropsychiatric Disease and Treatment. 2019 | Pubmed ID: 30936699 Research Progress on Classical Traditional Chinese Medicine Formula Lily Bulb and Rehmannia Decoction in the Treatment of Depression Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. Apr, 2019 | Pubmed ID: 30780102 Chinese Herbal Medicine Wenxia Changfu Formula Reverses Cell Adhesion-Mediated Drug Resistance Via the Integrin β1-PI3K-AKT Pathway in Lung Cancer Journal of Cancer. 2019 | Pubmed ID: 30719123 Anti-Inflammatory Effect of IL-37-Producing T-Cell Population in DSS-Induced Chronic Inflammatory Bowel Disease in Mice International Journal of Molecular Sciences. 12, 2018 | Pubmed ID: 30563054 Metabolomics Research Reveals the Mechanism of Action of Astragalus Polysaccharide in Rats with Digestive System Disorders Molecules (Basel, Switzerland). Dec, 2018 | Pubmed ID: 30558291 The Effects of Radix Astragali Water Abstract on Energy Metabolism in Rat Yang-Deficiency Cold Syndrome Model Through PPAR Signaling Pathway Evidence-based Complementary and Alternative Medicine : ECAM. 2018 | Pubmed ID: 30519272 Evaluation of the Performance of Serum MiRNAs As Normalizers in MicroRNA Studies Focused on Cardiovascular Disease Journal of Thoracic Disease. May, 2018 | Pubmed ID: 29997921 Electroacupunture Contributes to Recovery of Neurological Deficits in Experimental Stroke by Activating Astrocytes Restorative Neurology and Neuroscience. 2018 | Pubmed ID: 29758953 HSF1 Deficiency Accelerates the Transition from Pressure Overload-induced Cardiac Hypertrophy to Heart Failure Through Endothelial MiR-195a-3p-mediated Impairment of Cardiac Angiogenesis Journal of Molecular and Cellular Cardiology. 05, 2018 | Pubmed ID: 29626503 Differential Cardiac Hypertrophy and Signaling Pathways in Pressure Versus Volume Overload American Journal of Physiology. Heart and Circulatory Physiology. 03, 2018 | Pubmed ID: 29196344 Efficacy of Low Carbohydrate Diet for Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-analysis of Randomized Controlled Trials Diabetes Research and Clinical Practice. Sep, 2017 | Pubmed ID: 28750216 MECHANISMS OF COIX SEED COMPOSITIONS IN THE TREATMENT OF SPLEEN DEFICIENCY AND WET DAMPNESS ZHENG African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM. 2017 | Pubmed ID: 28638886 Ultrasound Biomicroscopy Validation of a Murine Model of Cardiac Hypertrophic Preconditioning: Comparison with a Hemodynamic Assessment American Journal of Physiology. Heart and Circulatory Physiology. Jul, 2017 | Pubmed ID: 28455286 Mitochondrial PKC-ε Deficiency Promotes I/R-mediated Myocardial Injury Via GSK3β-dependent Mitochondrial Permeability Transition Pore Opening Journal of Cellular and Molecular Medicine. 09, 2017 | Pubmed ID: 28266127 Aldehyde Dehydrogenase 2 Deficiency Blunts Compensatory Cardiac Hypertrophy Through Modulating Akt Phosphorylation Early After Transverse Aorta Constriction in Mice Biochimica Et Biophysica Acta. Sep, 2016 | Pubmed ID: 27239698 The Effects of Different Angiotensin II Type 1 Receptor Blockers on the Regulation of the ACE-AngII-AT1 and ACE2-Ang(1-7)-Mas Axes in Pressure Overload-induced Cardiac Remodeling in Male Mice Journal of Molecular and Cellular Cardiology. 08, 2016 | Pubmed ID: 27210827 Identification of Amino Acid Residues in Angiotensin II Type 1 Receptor Sensing Mechanical Stretch and Function in Cardiomyocyte Hypertrophy Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2015 | Pubmed ID: 26303226 Qiliqiangxin Improves Cardiac Function and Attenuates Cardiac Remodeling in Rats with Experimental Myocardial Infarction International Journal of Clinical and Experimental Pathology. 2015 | Pubmed ID: 26261541 Letter to the Editor: When What You See Might Not Be What You Get: Prudent Considerations of Anesthetics for Murine Echocardiography American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2015 | Pubmed ID: 26078381 Electro-acupuncture Up-regulates Astrocytic MCT1 Expression to Improve Neurological Deficit in Middle Cerebral Artery Occlusion Rats Life Sciences. Aug, 2015 | Pubmed ID: 26037401 Combination Treatment With Antihypertensive Agents Enhances the Effect of Qiliqiangxin on Chronic Pressure Overload-induced Cardiac Hypertrophy and Remodeling in Male Mice Journal of Cardiovascular Pharmacology. Jun, 2015 | Pubmed ID: 25806688 Qiliqiangxin Inhibits Angiotensin II-induced Transdifferentiation of Rat Cardiac Fibroblasts Through Suppressing Interleukin-6 Journal of Cellular and Molecular Medicine. May, 2015 | Pubmed ID: 25752645 A Protective Role of Ciglitazone in Ox-LDL-induced Rat microvascular Endothelial Cells Via Modulating PPARγ-dependent AMPK/eNOS Pathway Journal of Cellular and Molecular Medicine. Jan, 2015 | Pubmed ID: 25388834 CXCR6 Deficiency Attenuates Pressure Overload-induced Monocytes Migration and Cardiac Fibrosis Through Downregulating TNF-α-dependent MMP9 Pathway International Journal of Clinical and Experimental Pathology. 2014 | Pubmed ID: 25400729 Mitochondrial Aldehyde Dehydrogenase 2 Plays Protective Roles in Heart Failure After Myocardial Infarction Via Suppression of the Cytosolic JNK/p53 Pathway in Mice Journal of the American Heart Association. Sep, 2014 | Pubmed ID: 25237043 Insights into the Activation and Inhibition of Angiotensin II Type 1 Receptor in the Mechanically Loaded Heart Circulation Journal : Official Journal of the Japanese Circulation Society. 2014 | Pubmed ID: 24813328 Src is Required for Mechanical Stretch-induced Cardiomyocyte Hypertrophy Through Angiotensin II Type 1 Receptor-dependent β-arrestin2 Pathways PloS One. 2014 | Pubmed ID: 24699426 Aldehyde Dehydrogenase 2 Ameliorates Doxorubicin-induced Myocardial Dysfunction Through Detoxification of 4-HNE and Suppression of Autophagy Journal of Molecular and Cellular Cardiology. Jun, 2014 | Pubmed ID: 24434637 Gene Expression Profiling of Rat Livers with Yin-deficiency-heat Syndrome Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan. Jun, 2013 | Pubmed ID: 24024336 Naoxintong Protects Against Atherosclerosis Through Lipid-lowering and Inhibiting Maturation of Dendritic Cells in LDL Receptor Knockout Mice Fed a High-fat Diet Current Pharmaceutical Design. 2013 | Pubmed ID: 23438960 Olmesartan Attenuates Cardiac Remodeling Through DLL4/Notch1 Pathway Activation in Pressure Overload Mice Journal of Cardiovascular Pharmacology. Feb, 2013 | Pubmed ID: 23188126 Danhong Inhibits Oxidized Low-density Lipoprotein-induced Immune Maturation of Dentritic Cells Via a Peroxisome Proliferator Activated Receptor γ-mediated Pathway Journal of Pharmacological Sciences. 2012 | Pubmed ID: 22739234 [Influence of Aconiti Lateralis Radix Praeparata on Asthenia Cold Syndrome Rats with Whole Genome Gene Expression of Liver by Gene Chip Technique] Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. Feb, 2012 | Pubmed ID: 22667152 Up-regulation of BMP-2 Antagonizes TGF-β1/ROCK-enhanced Cardiac Fibrotic Signalling Through Activation of Smurf1/Smad6 Complex Journal of Cellular and Molecular Medicine. Oct, 2012 | Pubmed ID: 22283839 [Effects of Aconite Root on Energy Metabolism and Expression of Related Genes in Rats] Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. Sep, 2011 | Pubmed ID: 22256761 Salvianolic Acid B Suppresses Maturation of Human Monocyte-derived Dendritic Cells by Activating PPARγ British Journal of Pharmacology. Dec, 2011 | Pubmed ID: 21649636 Inhibition of Aldehyde Dehydrogenase 2 Activity Enhances Antimycin-induced Rat Cardiomyocytes Apoptosis Through Activation of MAPK Signaling Pathway Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. Dec, 2011 | Pubmed ID: 21123025 Another Possible Cell Source for Cardiac Regenerative Medicine: Reprogramming Adult Fibroblasts to Cardiomyocytes and Endothelial Progenitor Cells Medical Hypotheses. Mar, 2011 | Pubmed ID: 21087827 [Research on Medical Speciality of Traditional Chinese Medicines Using Dot-immunoblotting Method Based on Polyclonal Antibody Prepared from Traditional Chinese Medicines with Hot/cold Nature] Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. Feb, 2009 | Pubmed ID: 19459307 Molecular and Clinical Characterization of a Novel SCN5A Mutation Associated with Atrioventricular Block and Dilated Cardiomyopathy Circulation. Arrhythmia and Electrophysiology. Jun, 2008 | Pubmed ID: 19808398 Emodin Induces Growth Arrest and Death of Human Vascular Smooth Muscle Cells Through Reactive Oxygen Species and P53 Journal of Cardiovascular Pharmacology. May, 2007 | Pubmed ID: 17513942 Enhanced Myocardial Cathepsin B Expression in Patients with Dilated Cardiomyopathy European Journal of Heart Failure. May, 2006 | Pubmed ID: 16480925 Artery Interposed to Vein Did Not Develop Atherosclerosis and Underwent Atrophic Remodeling in Cholesterol-fed Rabbits Atherosclerosis. Nov, 2004 | Pubmed ID: 15488863 Surgically Induced Cardiac Volume Overload by Aortic Regurgitation in Mouse Jian Wu*1, Shijun Wang*1, Le Kang*1, Chunjie Yang*1, Jianguo Jia1, Xingxu Wang2, Ge Wei1, Xuan Li1, Jieyun You2, Yunzeng Zou1 1Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, 2Department of Cardiovascular Medicine, Shanghai East Hospital, School of Medicine, Tongji University JoVE 63579 Biology A New Model of Heart Failure Post-Myocardial Infarction in the Rat Honglei Li1,2, Jiansheng Huang3, Caihong Liu1, Zhentao Zhang3, Kuiquan Song2, Ke Ma1, Connor W. Dennewitz3, Shijun Wang1,4 1College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, 2Department of Intensive Care Unit, Jinan Municipal Hospital of Traditional Chinese Medicine, 3Department of Medicine, Vanderbilt University Medical Center, 4Shandong Co-Innovation Center of Classic TCM Formula, Shandong Provincial Education Department JoVE 62540 Medicine
Surgically Induced Cardiac Volume Overload by Aortic Regurgitation in Mouse Jian Wu*1, Shijun Wang*1, Le Kang*1, Chunjie Yang*1, Jianguo Jia1, Xingxu Wang2, Ge Wei1, Xuan Li1, Jieyun You2, Yunzeng Zou1 1Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, 2Department of Cardiovascular Medicine, Shanghai East Hospital, School of Medicine, Tongji University JoVE 63579 Biology
A New Model of Heart Failure Post-Myocardial Infarction in the Rat Honglei Li1,2, Jiansheng Huang3, Caihong Liu1, Zhentao Zhang3, Kuiquan Song2, Ke Ma1, Connor W. Dennewitz3, Shijun Wang1,4 1College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, 2Department of Intensive Care Unit, Jinan Municipal Hospital of Traditional Chinese Medicine, 3Department of Medicine, Vanderbilt University Medical Center, 4Shandong Co-Innovation Center of Classic TCM Formula, Shandong Provincial Education Department JoVE 62540 Medicine