1Department of Medicine, Division of Cardiology,University of Miami Leonard M. Miller School of Medicine, 2Interdisciplinary Stem Cell Institute,University of Miami Leonard M. Miller School of Medicine, 3Department of Molecular and Cellular Pharmacology,University of Miami Leonard M. Miller School of Medicine, 4Department of Medical Education,University of Miami Leonard M. Miller School of Medicine
This protocol presents a detailed approach to replicating a murine model of hyperlipidemia-induced heart failure with preserved ejection fraction (HFpEF). The design combines the administration of adeno-associated virus 9-cardiac troponin T-low-density lipoprotein receptor (AAV9-cTnT-LDLR) and poloxamer-407 (P-407).
