Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation <em>In Vivo</em> and Decreasing Galactose-Deficient IgA1 Production <em>In Vitro</em>

Lan Lin; JiaChen Shen; XiaoCong Wu; Yun You; Shen Li

doi:10.3791/65719

Treating Immunoglobulin A Nephropathy (IgAN) with Dioscin in a Murine Model

October 13, 2023

Author Spotlight: Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro

02:29 min

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Lan Lin*¹, JiaChen Shen*², XiaoCong Wu, Yun You, Shen Li

¹Department of Nephrology,Guanganmen Hospital, ²Department of Nephrology,906 Hospital of Joint Logistic Support Force of People’s Liberation Army (PLA), ³Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences

Summary

This study provides experimental data for treating immunoglobulin A nephropathy (IgAN) with Dioscin (DIO), the active ingredient of Dioscoreae Nipponicae Rhizoma (DNR), and a paradigm for studying herbal medicine’s effects and underlying mechanisms in vivo and in vitro.

Treating Immunoglobulin A Nephropathy (IgAN) with Dioscin in a Murine Model

Author Spotlight: Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro

Summary

Article