Modeling Small Molecule Ligands in CryoEM Maps of Macromolecules

July 19, 2024

Modeling Ligands into Maps Derived from Electron Cryomicroscopy

Modeling Phosphoenolpyruvate in Enolase Enzyme from Mycobacterium tuberculosis

Shaileshanand Jha*¹, Sucharita Bose*², Kutti R. Vinothkumar

¹National Centre for Biological Sciences,Tata Institute of Fundamental Research, ²Institute for Stem Cell Science and Regenerative Medicine

Summary

This protocol introduces the tools available for modeling small-molecule ligands in cryoEM maps of macromolecules.

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