Chapter 27
Extracellular Matrix in Animals
![The Extracellular Matrix](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13336.jpg)
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM).…
![Glycosaminoglycans](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13337.jpg)
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino…
![Fibril-associated Collagen](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13339.jpg)
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated…
![Elastin is Responsible for Tissue Elasticity](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13340.jpg)
Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it…
![Matrix Proteoglycans and Glycoproteins](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13342.jpg)
Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage,…
![Role of Matrix Metalloproteases in Degradation of ECM](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13343.jpg)
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential…
![Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry](https://cloudfront.jove.com/files/thumbs/55674_t.png)
Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry
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Fibrosis is a hallmark of many cardiovascular diseases and is associated with the exacerbated secretion and deposition of the extracellular matrix…
![Assessing Collagen and Elastin Pressure-dependent Microarchitectures in Live, Human Resistance Arteries by Label-free Fluorescence Microscopy](https://cloudfront.jove.com/files/thumbs/57451_t.png)
The pathogenic contribution of resistance artery remodeling is documented in essential hypertension, diabetes and the metabolic syndrome.…