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Immunology and Infection

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JoVE Journal Immunology and Infection
Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
 
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Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Article DOI: 10.3791/3140-v • 11:29 min • October 7th, 2011
October 7th, 2011 •
1, 2
1Center for Autophagy Research, Department of Internal Medicine, UT Southwestern Medical Center, 2Department of Microbiology, UT Southwestern Medical Center

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We describe a protocol to identify key roles of host signaling molecules in lytic replication of a model herpesvirus, gamma herpesvirus 68 (γHV68). Utilizing genetically modified mouse strains and embryonic fibroblasts for γHV68 lytic replication, the protocol permits both phenotypic characterization and molecular interrogation of virus-host interactions in viral lytic replication.

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Host-virus Interaction Lytic Replication Model Herpesvirus Viral Infection Innate Immune Signaling Pathways Antiviral Cytokine Production Viral Evasion Signaling Pathways Manipulation Therapeutic Strategies Murine γHV68 Kaposi's Sarcoma-associated Herpesvirus Epsten-Barr Virus Small Animal Model Phenotypic Characterization Molecular Dissection Host Signaling Components Genetically Modified Mouse Strains Acute Infection Mouse Embryonic Fibroblasts (MEFs) Virological Assays Molecular Biology Assays
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