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Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies
 

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies

Article DOI: 10.3791/50331-v • 11:22 min • April 29th, 2013
April 29th, 2013 •
1, 1, 1, 2, 1
1Department of Neurology, University of Michigan, 2Department of Internal Medicine, University of Michigan

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总结概括
Automatic Translation

In order to study the changes of nociceptive intraepidermal nerve fibers (IENFs) in painful neuropathies (PN), we developed protocols that could directly examine three-dimensional morphological changes observed in nociceptive IENFs. Three-dimensional analysis of IENFs has the potential to evaluate the morphological changes of IENF in PN.

Tags

3D Imaging Nociceptive Intraepidermal Nerve Fibers Human Skin Biopsies Punch Biopsy IENFD Peripheral Polyneuropathy Distal Leg Proximal Thigh Length-dependent Polyneuropathies Multidirectional Nature Two-dimensional Imaging Three-dimensional Imaging Painful Neuropathy Immunofluorescent Analysis Protein Gene Product 9.5 (PGP) Small Fiber Neuropathies Brightfield Microscopy Double Immunofluorescent Analysis Tropomyosin-receptor-kinase A (Trk A) High Affinity Receptor For Nerve Growth Factor (NGF) Co-staining
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