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JoVE Journal Bioengineering
The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering
 

The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

Article DOI: 10.3791/54676-v • 08:53 min • November 2nd, 2016
November 2nd, 2016 •
1, 1, 1, 1,2, 3, 1, 1
1Department of Plastic and Hand Surgery and Laboratory for Tissue Engineering and Regenerative Medicine, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), 2Genetic Engineering and Biotechnology Institute for Postgraduate Studies, Baghdad University, 3Department of Plastic, Hand and Microsurgery, Sana Klinikum Hof GmbH

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We describe a microsurgical approach for the generation of an arteriovenous (AV) loop as a model for analyzing vascularization in vivo in an isolated and well-characterized environment. This model is not only useful for the investigation of angiogenesis, but is also optimally suited for engineering axially vascularized and transplantable tissues.

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Arteriovenous (AV) Loop Small Animal Model Angiogenesis Vascularized Tissue Engineering Microsurgical Approach Living Bio Reactors Axiolly Vascularized Tissue Individual Patient's Requirements Vascular Access Oxygen And Nutrients Supply Angiostenosis Processes Cancer Angiogenesis Micro Anastomosis Submillimeter Vessel Tissue Defects Atholo Vascularized Tissue Anesthesia Drug Doses
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