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Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
JoVE 杂志
医学
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JoVE 杂志 医学
Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

DOI:
10.3791/55553-v

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09:17 min

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May 02, 2017

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, , , , ,
1Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine,KU Leuven

Chapters

  • 00:05Title
  • 00:54Venous Line Preparation and Chronic Indwelling Catheter Placement
  • 05:06Cecal Ligation and Puncture (CLP)
  • 07:06Results: Representative Survival Curves after 5 or 7 Days of Critical Illness
  • 08:08Conclusion

Summary

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This protocol describes a centrally catheterized mouse model of prolonged critical illness. We combine the cecal ligation and puncture method to induce sepsis with the use of a central venous line for fluids, drugs and nutrient administration to mimic the human clinical setting.

Tags

Central Venous LineFluidsDrugsNutrient AdministrationMouse ModelCritical IllnessCecal Ligation And Puncture (CLP)Intensive CareEndocrineMetabolicAnesthesiaSurgical TechniqueCatheterWire LoopMouse PositioningSkin IncisionMuscle Exposure

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