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Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits
JoVE 杂志
医学
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JoVE 杂志 医学
Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

DOI:
10.3791/60126-v

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07:43 min

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January 08, 2020

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, , ,
1Department of Ophthalmology,Stony Brook University, 2Department of Medicine,Stony Brook University, 3Medicon Pharmaceuticals, Inc, 4Department of Preventive Medicine,Stony Brook University

Chapters

  • 00:04Title
  • 01:11Removal of the Nictitating Membrane
  • 02:24Complete Surgical Dacryoadenectomy
  • 06:43Results: Confirmation of Dry Eye Disease Post Dacryoadenectomy
  • 07:16Conclusion

Summary

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A novel approach is presented to induce chronic dry eye disease in rabbits by surgically removing all orbital lacrimal glands. This method, distinct from those previously reported, produces a stable, reproducible model of aqueous deficient dry eye well suited to study tear physiology and pathophysiology and ocular therapeutics.

Tags

Keywords: Severe Dry EyeDacryoadenectomyRabbit ModelAqueous Deficient Dry EyeLacrimal Gland RemovalNictitating MembraneOrbital Superior Lacrimal GlandSurgical TechniqueSurgical AnatomyOphthalmology Research

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