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A Murine Tail Lymphedema Model
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医学
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JoVE 杂志 医学
A Murine Tail Lymphedema Model

A Murine Tail Lymphedema Model

DOI:
10.3791/61848-v

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04:38 min

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February 10, 2021

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, , , , ,
1Department of Surgery, Indiana Center for Regenerative Medicine and Engineering,Indiana University School of Medicine

Chapters

  • 00:04Introduction
  • 00:53Surgical Disruption of Mouse Tail Lymphatics
  • 02:33Functional Lymphatic Evaluation with Near Infrared Laser Angiography
  • 02:54Result: Assessment of Progressive Swelling, Lymphatic Function, and Focal Delivery of Genetic Cargo in the Mouse Tail Lymphedema Model
  • 04:09Conclusion

Summary

自动翻译

自动翻译

Lymphedema is extremity swelling caused by lymphatic dysfunction. We describe a chronic murine tail model of lymphedema and the novel use of tissue nanotransfection technology (TNT) for genetic cargo delivery to the tail.

Tags

LymphedemaMurineTail ModelAxillary Lymph NodeBreast CancerHistologySkin ExcisionIsosulfan BlueLymphatic TransectionIndocyanine GreenNear-infrared Laser Angiography

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