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Enrichment of Host Cell Proteins in Monoclonal Antibody Drug Products
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Detecting Low-Abundant Host Cell Proteins in Drug Products Using Enrichment Beads and Limited Digestion
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JoVE 杂志 化学
Host Cell Protein Analysis using Enrichment Beads Coupled with Limited Digestion

Detecting Low-Abundant Host Cell Proteins in Drug Products Using Enrichment Beads and Limited Digestion

Enrichment of Host Cell Proteins in Monoclonal Antibody Drug Products

DOI:
10.3791/65544-v

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02:35 min

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January 19, 2024

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, ,
1Analytical Chemistry,Regeneron Pharmaceuticals Inc.

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Host Cell ProteinHCP AnalysisProteome Enrichment BeadsLimited DigestionDynamic RangeProteoMiner TechnologyNano LC-MS/MSMonoclonal AntibodyTherapeutic ProteinsImpuritiesRisk Assessment

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