Isothermal Titration Calorimetry for Evaluating PROTACS-Induced Ternary Complex Formation

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Isothermal Titration Calorimetry for Evaluating PROTACS-Induced Ternary Complex Formation (Video) | JoVE

Published: January 12, 2024

doi:

10.3791/200654

Wei Jiang, Holly Soutter

¹Center for the Development of Therapeutics,The Broad Institute of MIT and Harvard

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Keywords: Isothermal Titration Calorimetry PROTACS Ternary Complex Formation Protein DMSO Micro Calorimeter Titration Binary Complex VHL MZ1 Brd4 Positive Cooperativity

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Isothermal Titration Calorimetry for Evaluating PROTACS-Induced Ternary Complex Formation. J. Vis. Exp. (Pending Publication), e200654, doi:10.3791/200654 (2024).

Isothermal Titration Calorimetry for Evaluating PROTACS-Induced Ternary Complex Formation (Video) | JoVE

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