CNRS, UMR 7210 1 article published in JoVE Medicine Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis Nacim Bouheraoua*1,2,3,4, Lea Jouve*1,2,3,4, Vincent Borderie1,2,3,4, Laurent Laroche1,2,3,4 1Quinze-Vingts National Ophthalmology Hospital, 2INSERM UMR S 968, Institut de la Vision, 3Sorbonne Universités, UPMC Univ Paris 06, 4CNRS, UMR 7210 Corneal collagen cross-linking (CXL) is the only conservative treatment currently available to halt keratoconus progression by improving the biomechanical rigidity of the corneal stroma. The aim of this manuscript is to highlight the methods of three different protocols of CXL: conventional CXL (C-CXL), accelerated CXL (A-CXL), and iontophoresis CXL (I-CXL).