Chapter 29
Cell-Cell Interactions
![Cell Adhesion Molecules - Types and Functions](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13360.jpg)
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical…
![Structure of Cadherins](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13354.jpg)
The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins” is based on their…
![Catenins](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13355.jpg)
Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction…
![Selectins](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13362.jpg)
Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type,…
![Overview of Cell-Cell Junctions](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13353.jpg)
The complex three-dimensional arrangement of cells in any multicellular organism is defined and maintained by interactions of cells with each other…
![Adherens Junctions](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13356.jpg)
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – …
![Desmosomes](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13357.jpg)
The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first…
![Tight Junctions](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13359.jpg)
Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments…
![Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules](https://cloudfront.jove.com/files/thumbs/51762_t.png)
Cell-cell adhesion is fundamental to multicellular life and is mediated by a diverse array of cell surface proteins. However, the adhesive…
![Gap Junctional Intercellular Communication: A Functional Biomarker to Assess Adverse Effects of Toxicants and Toxins, and Health Benefits of Natural Products](https://cloudfront.jove.com/files/thumbs/54281_t.png)
This protocol describes a scalpel loading-fluorescent dye transfer (SL-DT) technique that measures intercellular communication through gap junction…
![Real-time Imaging of Endothelial Cell-cell Junctions During Neutrophil Transmigration Under Physiological Flow](https://cloudfront.jove.com/files/thumbs/51766_t.png)
Real-time Imaging of Endothelial Cell-cell Junctions During Neutrophil Transmigration Under Physiological Flow
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During inflammation, leukocytes leave the circulation and cross the endothelium to fight invading pathogens in underlying tissues. This process is…