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Journal / Behavior / Stereotaxic Microinjection of Viral Vectors…
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Behavior

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JoVE Journal Behavior
Stereotaxic Microinjection of Viral Vectors Expressing Cre Recombinase to Study the Role of Target Genes in Cocaine Conditioned Place Preference
 

Stereotaxic Microinjection of Viral Vectors Expressing Cre Recombinase to Study the Role of Target Genes in Cocaine Conditioned Place Preference

Article DOI: 10.3791/50600-v • 08:22 min • July 30th, 2013
July 30th, 2013 •
1,2, 1,2
1Graduate Program in Neuroscience, Weill Cornell Graduate School of Biomedical Sciences, 2Division of Pediatric Neurology, Department of Pediatrics, Weill Cornell Medical College

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Summary
Automatic Translation

This article describes how to microinject viral vectors into mouse brain and then test in a conditioned place preference paradigm that includes an acquisition, extinction and reinstatement phase.

Tags

Stereotaxic Microinjection Viral Vectors Cre Recombinase Target Genes Cocaine Conditioned Place Preference Gene Deletion Conditional Deletion Floxed Gene Brain Regions Temporally-specific Control Regionally-specific Control Experimenter-determined Time Points Behavioral Paradigms Self-administration Psychomotor Sensitization Withdrawal Extinction Reinstatement Phases Cocaine-induced Plasticity Selective Ablation Addictive Behavior
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