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Fenotypering Mouse Longfunctie<em> In Vivo</em> Met de Lung diffusiecapaciteit
JoVE Journal
Biologie
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JoVE Journal Biologie
Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity
DOI:

07:13 min

January 06, 2015

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Kapitel

  • 00:05Titel
  • 01:18Setting up the Gas Chromotagraph
  • 02:24Measuring the Diffusion Factor for Carbon Monoxide (DFCO)
  • 04:46Results: Changes in DFCO in Different Pathologies
  • 06:39Conclusion

Summary

Automatische Übersetzung

We describe a means to quickly and simply measure the lung diffusing capacity in mice and show that it is sufficiently sensitive to phenotype changes in multiple common lung pathologies. This metric thus brings direct translational relevance to the mouse models, since diffusing capacity is also easily measured in humans.

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