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A Small Animal Model of Ex Vivo Normothermic Liver Perfusion
 

A Small Animal Model of Ex Vivo Normothermic Liver Perfusion

Article DOI: 10.3791/57541-v • 08:32 min • June 27th, 2018
June 27th, 2018 •
1,2, 1, 1,2, 1,2, 1, 1, 3, 4, 2, 1,3, 1,2
1Collaboration for Organ Perfusion, Protection, Engineering and Regeneration (COPPER) Lab, Division of Transplant, Department of Surgery, Comprehensive Transplant Center, Ohio State University Wexner Medical Center, 2Department of Surgery, Division of Transplant, Ohio State University Wexner Medical Center, 3Department of Surgery, Division of CardioThoracic Surgery, Ohio State University Wexner Medical Center, 4Department of Medicine, Ohio State University Wexner Medical Center

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Summary
Automatic Translation

There is a significant liver donor shortage, and criteria for liver donors have been expanded. Normothermic ex vivo liver perfusion (NEVLP) has been developed to evaluate and modify organ function. This study demonstrates a rat model of NEVLP and tests the ability of pegylated-catalase, to mitigate liver preservation injury.

Tags

Ex Vivo Normothermic Liver Perfusion Transplantation Organ Preservation Perfusates Perfusate Additives Software For Organ Evaluation Repairing Organs Advantage Of Normothermic Ex Vivo Liver Perfusion Model 16 Gauge Portal Cuff Tubing Hemostat Angiocatheter Bile Duct Cannula Anesthesia Nose Cone Vital Signs Monitoring Toe Pinch Anesthesia Test 70% Isopropyl Alcohol Sterile Drape Midline Incision
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