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Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination
 

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

Article DOI: 10.3791/61593-v • 05:39 min • February 9th, 2021
February 9th, 2021 •
1, 1, 1, 1, 1, 1,2,3
1Respiratory Medicine, Nagoya University Graduate School of Medicine, 2Nagoya University Institute for Advanced Research, 3B3-Unit, Advanced Analytical and Diagnostic Imaging Center (AADIC)/Medical Engineering Unit (MEU), Nagoya University Institute for Advanced Research

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Summary
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Near-infrared photoimmunotherapy (NIR-PIT) is an emerging cancer therapeutic strategy that utilizes an antibody-photoabsorber (IR700Dye) conjugate and NIR light to destroy cancer cells. Here, we present a method to evaluate the antitumor effect of NIR-PIT in a mouse model of pleural disseminated lung cancer and malignant pleural mesothelioma using bioluminescence imaging.

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Near Infrared Photoimmunotherapy NIR-PIT Thoracic Tumors Pleural Dissemination Mouse Model Therapeutic Effects Tumor Model Polystyrene Foam Stopper Disinfect Needle Target Tumor Cells Pedal Reflex Anesthetized Mouse Intercostal Space Ribs Cell Injection Thoracic Cavity Monitoring Recovery D-luciferin
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