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Journal
/
Biotechnik
/
Closed System Production of Adherent Cells Based on Dissolvable Microcarriers
/
Author Spotlight: Advancing Cell Therapy Manufacturing with Dissolvable Microcarriers
JoVE Journal
Biotechnik
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JoVE Journal
Biotechnik
Large-Scale Cell Production Based on GMP-Grade Dissolvable Porous Microcarriers
Author Spotlight: Advancing Cell Therapy Manufacturing with Dissolvable Microcarriers
Closed System Production of Adherent Cells Based on Dissolvable Microcarriers
DOI:
10.3791/65469-v
•
02:13 min
•
July 07, 2023
•
Yuyang Chen*
1
,
Huanye Xu*
2
,
Yuanyuan Zhang*
2
,
Leilei Guo
,
Miaomiao Lan
,
Yanping Yang
,
Wei Liu
,
Xiaojun Yan
,
Yanan Du
1
Department of Biomedical Engineering, School of Medicine
,
Tsinghua University
,
2
Beijing CytoNiche Biotechnology Co. Ltd.
Tags
Cell And Gene Therapy
Large-scale Cell Production
GMP-grade Dissolvable Porous Microcarriers
Automated Closed System
Stirred-tank Bioreactor
Adherent Cells
Cell Harvesting
Mesenchymal Stem Cells
HEK293T Cells
Vero Cells
Industrial-scale Manufacturing
Quality Control
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Author Spotlight: Advancing Cell Therapy Manufacturing with Dissolvable Microcarriers
Preparation of the Stirred-Tank Bioreactor for Large-Scale Production of Human Mesenchymal Stem Cells
Two-Tiered Expansion of Human Mesenchymal Stem Cells from 5-Liter to 15-Liter Bioreactors and Automated Cell Formulation from a 15-Liter Bioreactor
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