Establishing a Physiologic Human Vascularized Micro-Tumor Model for Cancer Research

Stephanie J. Hachey; Daniela Gaebler; Christopher C. W. Hughes

doi:10.3791/65865

Preparing a Microfluidics-Based Vascularized Human Micro-Tumor Model

September 15, 2023

Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research (Video) | JoVE

01:43 min

•

Preparing a Vascularized Micro-Tumor System Using Human Cells for Studying Tumors and Drug Responses (Video) | JoVE

01:55 min

•

Introducing Human Cells into a Microfluidic Device to Investigate Tumor Progression in a Vascularized Micro-Tumor System (Video) | JoVE

03:51 min

•

Stephanie J. Hachey, Daniela Gaebler, Christopher C. W. Hughes²

¹Molecular Biology and Biochemistry,University of California, Irvine, ²Biomedical Engineering,University of California, Irvine

Summary

This protocol presents a physiologically relevant tumor-on-a-chip model to perform high-throughput basic and translational human cancer research, advancing drug screening, disease modeling, and personalized medicine approaches with a description of loading, maintenance, and evaluation procedures.

Preparing a Microfluidics-Based Vascularized Human Micro-Tumor Model

Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research (Video) | JoVE

Preparing a Vascularized Micro-Tumor System Using Human Cells for Studying Tumors and Drug Responses (Video) | JoVE

Introducing Human Cells into a Microfluidic Device to Investigate Tumor Progression in a Vascularized Micro-Tumor System (Video) | JoVE

Summary

Article