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Tibial Nerve Transection - A Standardized Model for Denervation-induced Skeletal Muscle Atrophy in Mice
 

Tibial Nerve Transection - A Standardized Model for Denervation-induced Skeletal Muscle Atrophy in Mice

Article DOI: 10.3791/50657-v • 10:50 min • November 3rd, 2013
November 3rd, 2013 •
1, 2
1Keenan Research Centre of the LiKaShing Knowledge Institute, St Michaels Hospital, 2Department of Surgery, McMaster University

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Resumen
Automatic Translation

The tibial nerve transection model is a well-tolerated, validated, and reproducible model of skeletal muscle atrophy. The model surgical protocol is described and demonstrated in C57Black6 mice.  

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Tibial Nerve Transection Denervation-induced Skeletal Muscle Atrophy Mice Model Reproducible Model Rodents Muscle Atrophy Peroneal Nerve Sural Nerve Sciatic Nerve Transection Morbidity Ambulation Physiologic Mechanisms Cellular Mechanisms Molecular Biologic Mechanisms Muscle Fiber Types Gastrocnemius Muscle Muscle Weights Cross-sectional Area
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