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Immunology and Infection

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JoVE Journal Immunology and Infection
Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice
 

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice

Article DOI: 10.3791/60048-v • 08:43 min • January 31st, 2020
January 31st, 2020 •
*1,2, *1,2, *1,2, *1,2, *1,2, *1,2, *1,2, *1,2, *1,2
1Medical School of Hebei University, 2Key Laboratory of Pathogenesis Mechanism and Control of Inflammatory-Autoimmune Diseases in Hebei Province
* These authors contributed equally

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This protocol uses G6PI mixed peptides to construct rheumatoid arthritis models that are closer to that of human rheumatoid arthritis in CD4+ T cells and cytokines. High purity invariant natural killer T cells (mainly iNKT2) with specific phenotypes and functions were obtained by in vivo induction and in vitro purification for adoptive immunotherapy.

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Adoptive Immunotherapy INKT Cells Glucose-6-Phosphate Isomerase (G6PI) RA Model T Cells B Cells Innate Immunity Pathogenesis Of RA Immunomodulatory Effects Clinical Application Technology Simple Operation Copyable Procedure Chen Shengde Gao Xiang Zhang Jingnan HGPI325 To 339 Fragments HGPI469 To 483 Fragments Complete Freund's Adjuvant Emulsification Unit
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