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Enrichment of Host Cell Proteins in Monoclonal Antibody Drug Products

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Detecting Low-Abundant Host Cell Proteins in Drug Products Using Enrichment Beads and Limited Digestion

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Host Cell Protein Analysis using Enrichment Beads Coupled with Limited Digestion

Detecting Low-Abundant Host Cell Proteins in Drug Products Using Enrichment Beads and Limited Digestion

Enrichment of Host Cell Proteins in Monoclonal Antibody Drug Products

DOI:

10.3791/65544-v

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02:35 min

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January 19, 2024

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Sisi Zhang, Hui Xiao, Ning Li

¹Analytical Chemistry,Regeneron Pharmaceuticals Inc.

Tags

Host Cell Protein HCP Analysis Proteome Enrichment Beads Limited Digestion Dynamic Range ProteoMiner Technology Nano LC-MS/MS Monoclonal Antibody Therapeutic Proteins Impurities Risk Assessment

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