Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder

Kristin K. Sellers; Ankit N. Khambhati; Noah Stapper; Joline M. Fan; Vikram R. Rao; Katherine W. Scangos; Edward F. Chang; Andrew D. Krystal

doi:10.3791/65177

Deep Brain Stimulation for Treatment of Major Depression

July 07, 2023

Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment (Video) | JoVE

01:13 min

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Neurostimulation System Setup and Symptom Collection for Patient At-Home Recordings (Video) | JoVE

01:44 min

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Procedure for Concurrent At-Home Symptom Reports and Neural Recordings (Video) | JoVE

01:21 min

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Programming Device Detector Settings for Closed-Loop Neurostimulation

01:42 min

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Kristin K. Sellers², Ankit N. Khambhati², Noah Stapper³, Joline M. Fan⁴, Vikram R. Rao⁴, Katherine W. Scangos³, Edward F. Chang², Andrew D. Krystal³

¹Department of Neurological Surgery,University of California, San Francisco, ²Weill Institute for Neurosciences,University of California, San Francisco, ³Department of Psychiatry and Behavioral Sciences,University of California, San Francisco, ⁴Department of Neurology,University of California, San Francisco

Summary

Deep brain stimulation triggered by a patient-specific neural biomarker of a high-symptom state may better control symptoms of major depressive disorder compared to continuous, open-loop stimulation. This protocol provides a workflow for identifying a patient-specific neural biomarker and controlling the delivery of therapeutic stimulation based on the identified biomarker.