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Induction and Evaluation of Experimental Autoimmune Encephalomyelitis in Mouse

October 13, 2023
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Modellering af multipel sklerose hos de to køn: MOG35-55-induceret eksperimentel autoimmun encephalomyelitis

02:08 min
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Preparation of MOG35-55 Emulsion for Immunization of Mouse

01:01 min
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Immunization of Mouse with MOG35-55 to Induce Experimental Autoimmune Encephalomyelitis

00:56 min
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Clinical Score and Motor Performance Evaluation of Mouse Induced with Experimental Autoimmune Encephalomyelitis

01:52 min
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1Neuroscience Institute Cavalieri Ottolenghi (NICO), 2Department of Neuroscience “Rita Levi-Montalcini”,University of Turin, 3School of Pharmacy, Pharmacology Unit,University of Camerino, 4Koelliker Hospital

Summary

Traduction automatique

Eksperimentel autoimmun encephalomyelitis er en af de mest anvendte murinmodeller af multipel sklerose. I den nuværende protokol immuniseres C57BL/6J-mus af begge køn med myelinoligodendrocytglycoproteinpeptid, hvilket hovedsageligt resulterer i stigende parese af halen og lemmerne. Her diskuterer vi protokollen for EAE-induktion og evaluering.

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