High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using <em>Drosophila melanogaster</em>

Zheng Zhang; Yuedong Wang; Jiaying Zhao; Shifeng Han; Zi Chao Zhang; Yao Tian

doi:10.3791/65787

Advancing Sleep Disorder Treatments: A Drosophila-Based Screening Approach

October 20, 2023

Overcoming Challenges in Drosophila Sleep Measurement Using DAM System (Video) | JoVE

01:35 min

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Drug Screening Method for Sleep Regulation in an Elderly Drosophila melanogaster Model (Video) | JoVE

01:51 min

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Analyzing the Effect of Reserpine on the Sleep Behavior of Drosophila melanogaster Using SCAMP2020 Data Package in MATLAB (Video) | JoVE

02:47 min

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Zheng Zhang, Yuedong Wang, Jiaying Zhao, Shifeng Han, Zi Chao Zhang, Yao Tian

¹School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease,Southeast University

Summary

Presented is a protocol for high-throughput drug screening to improve sleep by monitoring the sleep behavior of fruit flies in an elderly Drosophila model.

Advancing Sleep Disorder Treatments: A Drosophila-Based Screening Approach

Overcoming Challenges in Drosophila Sleep Measurement Using DAM System (Video) | JoVE

Drug Screening Method for Sleep Regulation in an Elderly Drosophila melanogaster Model (Video) | JoVE

Analyzing the Effect of Reserpine on the Sleep Behavior of Drosophila melanogaster Using SCAMP2020 Data Package in MATLAB (Video) | JoVE

Summary

Article