A 3D Blood-Brain Barrier Model Derived from Human Pluripotent Stem-Cells

October 20, 2023

体外血脑屏障重建，模拟和治疗神经系统疾病

准备细胞组装 3D 人干细胞来源的体外血脑屏障

构建3D人干细胞来源的体外血脑屏障

Camille Goldman*^1,2,3,4,5, Natalie Suhy*^1,2,3,4,5, Jessica E. Schwarz^2,3,4,5, Emily Ruth Sartori^2,3,4,5, Rikki B. Rooklin^2,3,4,5, Braxton R. Schuldt^2,3,4,5, Louise A. Mesentier-Louro^2,3,4,5, Joel W. Blanchard^2,3,4,5

¹Icahn School of Medicine at Mount Sinai, ²Black Family Stem Cell Institute at Mount Sinai, ³Ronald M. Loeb Center for Alzheimer’s Disease at Mount Sinai, ⁴Friedman Brain Institute at Mount Sinai, ⁵Nash Family Department of Neuroscience at Mount Sinai

Summary

血脑屏障（BBB）在维持稳定和健康的大脑环境方面起着至关重要的作用。血脑屏障功能障碍与许多神经系统疾病有关。我们开发了一种 3D 干细胞衍生的 BBB 模型，用于研究脑血管病理学、BBB 完整性以及 BBB 如何被遗传和疾病改变。

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