Assessing Rat Diaphragm Motor Unit Connectivity Outcome Measures as Quantitative Biomarkers of Phrenic Motor Neuron Degeneration and Compensation

Arsh Ketabforoush; Meifang Wang; Catherine L. Smith; William David Arnold; Nicole L. Nichols

doi:10.3791/66568

Quantifying Phrenic Motor Unit Function in Rodent Models of Neurodegeneration

April 19, 2024

Author Spotlight: Studying Neuromuscular Responses and Motor Neuron Plasticity in Neurodegenerative Diseases

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Arsh Ketabforoush*¹, Meifang Wang*¹, Catherine L. Smith, William David Arnold^3,4,5, Nicole L. Nichols^5,6

¹NextGen Precision Health,University of Missouri, ²Department of Biomedical Sciences,University of Missouri, ³Department of Physical Medicine and Rehabilitation,University of Missouri, ⁴Department of Neurology,University of Missouri, ⁵Department of Medical Pharmacology and Physiology,University of Missouri, ⁶Dalton Cardiovascular Research Center,University of Missouri

Summary

In this study, we present an in vivo method for estimating motor unit number and size to quantify rat diaphragm motor unit connectivity. A step-by-step approach to these techniques is described.

Quantifying Phrenic Motor Unit Function in Rodent Models of Neurodegeneration

Author Spotlight: Studying Neuromuscular Responses and Motor Neuron Plasticity in Neurodegenerative Diseases

Summary

Article