Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same …
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the …
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments …
The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes …
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and …
Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate domains …
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or …
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell …
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these …
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like …
As genomes of a wider variety of animals become available, there is an increasing need for tools that can capture dynamic epigenetic changes in these …
Liver repopulation after injury is a crucial feature of mammals which prevents immediate organ failure and death after exposure of environmental toxins. A …
