Morris水迷宫实验
Summary
Morris水迷宫是一个广为接受的的工具，用来记录海马参与行为的任务。
Abstract
Morris水迷宫是广泛用于研究空间记忆和学习。动物被放置在一个水池，颜色与非低脂牛奶或奶粉无毒温度油漆，他们必须游到一个隐藏的逃生平台不透明。 ，因为他们是在不透明的水，动物不能看到的平台，并不能依靠气味找到逃生路线。相反，他们必须依赖于外部/额外的迷宫线索。由于动物的任务变得更加熟悉，他们能够更迅速地找到平台。由Richard G.莫里斯在1984年开发，这种模式已成为“金标准”行为神经科学之一。
Protocol
设立水迷宫水迷宫成立的主要成分应该是圆池，约6英尺，直径约3英尺深。如果你是用摄像机录制的任务，确保各方的迷宫摄像机的视野内。 填充用自来水，应接近26 ° C的水迷宫这可能需要几个小时，因此提前做好应该做的。定期检查水的温度，因此，它是在26 ° C度将在池中心的逃生平台。在训练期间，它必须被暴露出来，一英寸以上的水。这教的老鼠，有一个平台，它是?…
Discussion
水迷宫任务是发展莫里斯5。这个任务可以改变在许多方面进行调查工作记忆，参考记忆和任务，战略6。这里所描述的过程包含两个关键变量，这代表了从其他版本的水迷宫偏差：训练前，并在一天的测试。
训练前 -海马在空间/关系内存7-8参与。特别是水迷宫测试空间记忆3。不过，也有许多其他组件的任务，不涉及空间记忆任务所涉及的压力，任务的规则（，…
Divulgations
The authors have nothing to disclose.
Acknowledgements
JLN支持68347氢。
Materials
| Material Name | Type | Company | Catalogue Number | Comment |
|---|---|---|---|---|
| SMART System | San Diego Instruments | This system is not a requirement – there are many other behavioral systems on the market. |
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Citer Cet Article
Nunez, J. Morris Water Maze Experiment. J. Vis. Exp. (19), e897, doi:10.3791/897 (2008).