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Chapitres
- 00:05Titre
- 02:04Integrated Multi-modal Imaging of Rabbit Atheromata
- 04:43Ex Vivo Fluorescence Reflectance Imaging (FRI) of Dissected Aorta and Iliac Arteries
- 06:20Analyses and Integration of Multi-modal Images (Angiography, IVUS, NIRF, and FRI)
- 07:37Representative Results
- 08:35Conclusion
We detail a new near-infrared fluorescence (NIRF) catheter for 2-dimensional intravascular molecular imaging of plaque biology in vivo. The NIRF catheter can visualize key biological processes such as inflammation by reporting on the presence of plaque-avid activatable and targeted NIR fluorochromes. The catheter utilizes clinical engineering and power requirements and is targeted for application in human coronary arteries. The following research study describes a multimodal imaging strategy that utilizes a novel in vivo intravascular NIRF catheter to image and quantify inflammatory plaque in proteolytically active inflamed rabbit atheromata.
Tags
In VivoNear Infrared FluorescenceNIRFIntravascular Molecular ImagingInflammatory PlaqueAtherosclerosisVascular ResponseInjuryInflammatory ResponseMacrophagesAccumulationLipid-laden Intra-luminal PlaqueSmooth Muscle Cell ProliferationNarrowing Of Vessel LumenVulnerable PlaquesAcute Myocardial InfarctionMolecular ImagingClinical ToolResearch ToolVisualization Of InflammationBiological ProcessesHigh-risk PlaquesPharmacotherapeuticsMRIPETCarotid ArteriesCoronary ArteriesHigh-resolution Optical Imaging Strategies
