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Chapitres
- 00:01Introduction
- 00:59Severity of Malaria Worldwide
- 01:27What is Plasmodium falciparum?
- 02:11The Dengue Virus
- 02:50Life cycle of Plasmodium falciparum
- 04:36Identification of Refractory Genes
- 06:37Physiological Mechanisms Employed by A. gambiae to Kill Plasmodium
- 07:32Physiological Mechanisms of Dengue Virus Resistance in A. aegypti
- 08:20Technological Advances Benefiting Mosquito-Borne Disease Research
- 09:51Drawbacks to Studying Laboratory-Maintained Mosquitoes
- 11:12Strategies for Preventing Malarial Transmission
- 12:28Ethical Considerations for Releasing Genetically Modified Mosquitoe
- 13:33Obstacles Preventing Disease Control Strategies
- 14:54End Credits
In this interview, George Dimopoulos focuses on the physiological mechanisms used by mosquitoes to combat Plasmodium falciparum and dengue virus infections. Explanation is given for how key refractory genes, those genes conferring resistance to vector pathogens, are identified in the mosquito and how this knowledge can be used to generate transgenic mosquitoes that are unable to carry the malaria parasite or dengue virus.
