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Hyperinsulinemic-Euglycemic Clamp in the Conscious Rat
 
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Hyperinsulinemic-Euglycemic Clamp in the Conscious Rat

Article DOI: 10.3791/2432-v • 11:12 min • February 7th, 2011
February 7th, 2011 •
1, 1,2, 2, 1,2
1Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, 2Faculty of Kinesiology, University of Calgary

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The hyperinsulinemic-euglycemic clamp is the "gold standard" for the assessment of insulin action. Insulin is infused at a constant rate stimulating glucose uptake. The amount of exogenous glucose infused to counter this drop is indicative of insulin sensitivity. Here the procedure is performed on a conscious, unrestrained rat.

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Hyperinsulinemic-euglycemic Clamp Type 2 Diabetes Insulin Sensitivity Blood Glucose Levels Insulin Production Insulin Utilization Gold-standard Hyperinsulinemic-euglycemic Clamp Procedure Infusion Of Insulin Drop In Blood Glucose Exogenous Glucose Venous Circulation Homeostasis Insulin Sensitivity Assessment Chronically Catheterized Rat Anesthesia Induction Carotid Artery Catheterization Jugular Vein Catheterization Heparinized Saline Flush Weight Gain Monitoring Fasting Insulin And D50 Infusion
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