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Chapitres
- 00:05Titre
- 02:25Tissue Processing
- 04:25Immunohistochemistry
- 06:54Representative GBM Tissue Images
- 08:29Conclusion
Here, we established a method for drug efficacy testing with surgical specimens of brain tumors, termed “tumor explant method”. With this method, we can evaluate drug efficacy without breaking the microenvironment of solid tumors. To validate reliability of this method, we describe representative data with our glioma specimen treated with the current first-line chemotherapeutic agent, temozolomide.
Tags
Novel Anti-cancer Drug DevelopmentTumor ExplantsSurgical SpecimensMalignant GliomaDrug Efficacy TestsPre-clinical PhaseIn Vitro CultureCell LinesPhenotypic AlterationsGenetic AlterationsEpigenetic AlterationsXenograft ModelsImmunodeficient MiceMicroenvironmentUndissociated Tumor BlocksTreatment Effects EvaluationTemozolomide (TMZ)Intratumoral InjectionDrug Candidates Analysis
