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Intraluminal Middle Cerebral Artery Occlusion (MCAO) Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Mice
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Journal JoVE Médecine
Intraluminal Middle Cerebral Artery Occlusion (MCAO) Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Mice

Intraluminal Middle Cerebral Artery Occlusion (MCAO) Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Mice

DOI:
10.3791/2879-v

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13:01 min

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May 08, 2011

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, , , ,
1Department of Neurosurgery,University of Florida, 2Department of Anatomical Sciences,Shiraz University of Medical Sciences

Chapitres

  • 00:05Titre
  • 00:43Introduction
  • 01:57Suture Preparation
  • 02:40Animal Preparation
  • 04:19Koizumi’s Method
  • 06:04Reperfusion
  • 06:27Longa’s Method
  • 09:19Neurological Evaluation After MCAO
  • 09:26Score 1
  • 09:41Score 2
  • 09:50Score 3
  • 10:03Score 4
  • 10:12Staining and Quantitative Measurement of Brain Infarct Volume
  • 10:57Representative Results
  • 11:55Conclusion

Summary

Traduction automatique

Traduction automatique

The intraluminal middle cerebral artery occlusion (MCAO) model is the most frequent used model among experimental ischemic stroke models. Here we will demonstrate the entire model in detail with the guide of Laser Doppler flowmetry, and its representative results.

Tags

Intraluminal Middle Cerebral Artery OcclusionMCAO ModelIschemic StrokeLaser Doppler Flowmetry GuidanceMiceThird Leading Cause Of DeathLeading Cause Of DisabilityCostUnited StatesRatModificationMolecular MechanismsBrain InjuryTherapeutic ModalitiesNoninvasive MethodTransgenic StrainsKnockout StrainsFocal Cerebral IschemiaIntraluminal SutureInternal Carotid ArteryBase Of The MCASpontaneous ReperfusionPermanent RetentionVideo DemonstrationDrawbacksPitfalls235-triphenyltetrazolium Chloride (TTC)Cerebral Infarction

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