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Delivery of Therapeutic Agents Through Intracerebroventricular (ICV) and Intravenous (IV) Injection in Mice
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Journal JoVE Médecine
Delivery of Therapeutic Agents Through Intracerebroventricular (ICV) and Intravenous (IV) Injection in Mice

Delivery of Therapeutic Agents Through Intracerebroventricular (ICV) and Intravenous (IV) Injection in Mice

DOI:
10.3791/2968-v

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05:55 min

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October 03, 2011

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, , , , ,
1Department of Molecular Microbiology and Immunology, Bond Life Sciences Center,University of Missouri, 2Department of Biological Sciences,Columbia University , 3Department of Veterinary Pathobiology, Bond Life Sciences Center,University of Missouri

Chapitres

  • 00:05Titre
  • 01:10Intracerebroventicular Injection
  • 03:45Intravenous Injection via the Temporal/Facial Vein
  • 05:28Conclusion

Summary

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This article demonstrates two very different methods of injection: 1) into the brain (intracerebroventricular) and 2) systemic (intravenous) to introduce the therapeutic agents into the central nervous system of neonatal mice.

Tags

Intracerebroventricular InjectionIntravenous InjectionTherapeutic AgentsBlood Brain BarrierCentral Nervous SystemNeurodegenerative DisordersSpinal Muscular AtrophyNeonatal MiceCerebral Lateral VentriclesCerebrospinal FluidTemporal Vein InjectionViral VectorViral SerotypeSystemic DeliveryPermeable Blood Brain Barrier

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