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Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
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Journal JoVE Bio-ingénierie
Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

DOI:
10.3791/3398-v

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06:47 min

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September 20, 2011

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, , , , , ,
1Laboratory of Nano- and Translational Medicine, Department of Radiation Oncology, Lineberger Comprehensive Cancer Center,University of North Carolina School of Medicine, 2Carolina Center for Nanotechnology Excellence,University of North Carolina

Chapitres

  • 00:05Titre
  • 01:27Synthesis of PLGA-b-PEG Polymer
  • 03:26PLGA-b-PEG Nanoparticle Preparation
  • 04:49Representative Analysis of Diblock Polymeric Nanoparticles
  • 05:51Conclusion

Summary

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This article describes a nanoprecipitation method to synthesize polymer-based nanoparticles using diblock co-polymers. We will discuss the synthesis of diblock co-polymers, the nanoprecipitation technique, and potential applications.

Tags

FormulationDiblock Polymeric NanoparticlesNanoprecipitation TechniqueNanotechnologyParticlesNanoparticlesEngineeredSizeCompositionSurface ChemistryCargo PropertiesSolubilityDiffusivityBiodistributionRelease CharacteristicsImmunogenicityDrug DeliveryImagingCell BiologyTechnical BarrierPolymer-based Nanoparticle PlatformHydrophobic DomainHydrophilic DomainPLGAPEGConjugation ReactionEDC/NHS ChemistryPolymer Purification ProcessSelf-assembleHydrophobic-hydrophilic InteractionsVersatile Nanoparticle

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