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Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)
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Médecine
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Journal JoVE Médecine
Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)

Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)

DOI:
10.3791/3936-v

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12:35 min

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March 17, 2012

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, , , , ,
1Dept. of Neurology,University Medicine Göttingen, 2DFG Research Center for the Molecular Physiology of the Brain (CMPB),Göttingen, Germany

Chapitres

  • 00:02Titre
  • 01:07Clinical Testing of the SOD G93A Mouse Model of ALS
  • 02:03Hanging Wire Test
  • 03:05Rotarod Test
  • 04:30Spinal Cord Preparation
  • 10:55Spinal Cord Immunohistochemistry
  • 11:41Conclusions

Summary

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Traduction automatique

A mouse model for amyotrophic lateral sclerosis (ALS) is examined clinically and behaviorally. As a prerequisite for an accompanying immunohistological analysis the preparation of the spinal cord is depicted in detail.

Tags

Clinical TestingSpinal Cord RemovalMouse ModelAmyotrophic Lateral SclerosisALSNeurodegenerative DisorderMotoneuronsFamilial MutationsSOD GeneSOD1 (G93A) MutationOverall SurvivalClinical CourseMotor FunctionBehavioural Motor TestsQuantitative Scoring SystemsImmunohistochemical ExaminationSpinal Cord PreparationDorsal Laminectomy MethodHistological FindingsTherapeutic OptionsHuman Clinical Trials

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