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Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT
 

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT

Article DOI: 10.3791/4060-v • 10:53 min • November 23rd, 2012
November 23rd, 2012 •
1, 2, 1
1Department of Translational Imaging, The Methodist Hospital Research Institute, Houston, 2Diabetes Research Center, The Methodist Hospital Research Institute, Houston

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résumé
Automatic Translation

A method of functional imaging of mouse brown adipose tissue (BAT) is described in which cold-stimulated uptake of 18F-Fluorodeoxyglucose (FDG) in BAT is non-invasively assessed with a standardized micro-PET/CT protocol. This method is robust and sensitive to detect differences in BAT activities in mouse models.

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Functional Imaging Brown Fat Mice 18F-FDG Micro-PET/CT BAT (brown Adipose Tissue) WAT (white Adipose Tissue) Energy Expenditure Thermogenesis Sympathetic Nervous System Adrenergic Receptor Body Mass Index (BMI) Diabetic Parameters Anti-obesity/anti-diabetes Therapy Energy Balance Cold Challenge-based Positron Emission Tomography (PET) Standardized Protocol Small Animal Models C57BL/6J Mice Fasting Conditions 18F-Fluorodeoxyglucose (FDG) Micro-PET/CT System PET Images CT Images
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