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Stereotactic Intracranial Implantation and In vivo Bioluminescent Imaging of Tumor Xenografts in a Mouse Model System of Glioblastoma Multiforme
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Médecine
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Journal JoVE Médecine
Stereotactic Intracranial Implantation and In vivo Bioluminescent Imaging of Tumor Xenografts in a Mouse Model System of Glioblastoma Multiforme

Stereotactic Intracranial Implantation and In vivo Bioluminescent Imaging of Tumor Xenografts in a Mouse Model System of Glioblastoma Multiforme

DOI:
10.3791/4089-v

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10:52 min

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September 25, 2012

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, , , ,
1Department of Radiation Oncology,University of Pennsylvania

Chapitres

  • 00:05Titre
  • 02:08Orthotopic Xenograft Implantation
  • 07:41Bioluminescent Imaging (BLI) to Monitor Tumor Growth and Response to Therapy
  • 08:38Results: In Vivo Bioluminescent Imaging of Tumor Xenografts in a Mouse Model System of Glioblastoma Multiforme
  • 09:52Conclusion

Summary

Traduction automatique

Traduction automatique

We describe an integrated method for the precise, stereotactic implantation of human glioblastoma multiforme cells into the brains of nude mice and subsequent serial in vivo imaging to monitor growth and response to treatment of the resultant xenografts.

Tags

Stereotactic Intracranial ImplantationIn Vivo Bioluminescent ImagingTumor XenograftsMouse Model SystemGlioblastoma MultiformeHigh-grade Primary Brain CancerMedian SurvivalStandard Tri-modality TreatmentSurgical ResectionRadiation TherapyTemozolomide ChemotherapyTherapeutic ApproachesAnimal ModelsTumor GrowthTreatment ResponseBio-imageable GBM Cancer CellsNude MiceAnatomic LocationsIn Vivo Bioluminescent ImagingIntracranial Xenograft GrowthPerioperative MorbidityMortality

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