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Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
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Journal JoVE Médecine
Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia

DOI:
10.3791/4387-v

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07:46 min

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May 09, 2013

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, ,
1Department of Neurology, Center for Stroke Research Berlin,Charité – Universitätsmedizin Berlin, Germany

Chapitres

  • 00:05Titre
  • 01:19Positioning of the LDF Probe and LDF Monitoring
  • 02:24Bilateral Common Carotid Artery Occlusion
  • 04:10Middle Cerebral Artery Occlusion
  • 06:19Results: Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
  • 07:16Conclusion

Summary

Traduction automatique

Traduction automatique

There is accumulating evidence, that ischemic preconditioning (PC) – a non-damaging ischemic challenge to the brain - confers a transient protection to a subsequent damaging ischemic insult. We established bilateral common carotid artery occlusion (BCCAO) as a preconditioning stimulus to induce early ischemic tolerance (IT) to transient focal cerebral ischemia (induced by middle cerebral artery occlusion, MCAO) in C57Bl6/J mice.

Tags

Bilateral Common Carotid Artery OcclusionPreconditioning StimulusEarly Ischemic ToleranceFocal Cerebral IschemiaIschemic PreconditioningNon-damaging Ischemic ChallengeTransient ProtectionDamaging Ischemic InsultC57Bl6/J MiceMethodology

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