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Intranasal Administration of CNS Therapeutics to Awake Mice
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Médecine
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Journal JoVE Médecine
Intranasal Administration of CNS Therapeutics to Awake Mice

Intranasal Administration of CNS Therapeutics to Awake Mice

DOI:
10.3791/4440-v

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07:15 min

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April 08, 2013

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, , ,
1Alzheimer’s Research Center at Region’s Hospital,HealthPartners Institute for Education and Research

Chapitres

  • 00:05Titre
  • 01:20Acclimation to Handling for Intranasal Dosing to Awake Mice
  • 04:15Intranasal Delivery of Drug to Awake Mice
  • 05:57General Animal Handling Techniques for Acclimation and Intranasal Delivery of Drug to Awake Mice
  • 06:34Conclusion

Summary

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A method to intranasally administer drugs to awake mice for the purpose of targeting the brain is described. This method allows for repeat dosing over long periods using intranasal administration of drug without anesthesia, and nose-to-brain delivery with minimal systemic exposure.

Tags

Intranasal AdministrationCNS TherapeuticsAwake MiceNon-invasive DeliveryBlood-brain BarrierTargeted Drug DeliverySystemic ExposureIntranasal Delivery In Clinical TrialsPharmacokinetic DistributionEfficacy EvaluationAwake Delivery In MiceChronic Dosing Without AnesthesiaIntranasal Grip For Mice

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