5/6th Nephrectomy i kombinasjon med høy Salt Kosthold og nitrogenoksidsyntase Hemming å indusere kronisk nyresykdom i Lewis Rat

A two-stage method to establish chronic kidney disease (CKD) in the Lewis rat by surgically removing 5/6th of renal mass is described. Combination of the surgical procedure, NOS-inhibition and a high-salt diet leads to a model resembling human CKD, allowing study of causal mechanisms and development of novel therapeutic interventions.